Gestational Diabetes Mellitus. Diabetes mellitus arising in pregnancy
Conditions
Interventions
Intervention 1: In the intervention group, metformin 500 mg tablet was given twice a day to a maximum of 2500 mg/day based on glycemic profile that begins from 20 to 34 weeks gestational age and conti
Treatment - Drugs
In the intervention group, metformin 500 mg tablet was given twice a day to a maximum of 2500 mg/day based on glycemic profile that begins from 20 to 34 weeks gestational age and continue throughout o
In the control group, insulin 0.5 IU / kg as subcutaneous injection was started and titrated based on plasma glucose values from gestational age of 20 to 34 weeks and continue throughout of pregnancy.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1 - 18 to 40 years old pregnant women 2 - Singleton Pregnancy 3 - gestational age between 20 to 34 weeks (based on reliable LMP or ultrasound before 20 weeks of gestation) 3 - Diagnosis of GDM based on 2 or more abnormal values in GTT as per Carpenter and Coustan's criterion. Exclusion criteria: 1 - Systemic underlying disease (cardiovascular, pulmonary, renal , liver and autoimmune) 2 - Substance Abuse 3- Overt diabetes mellitus (except previous history of GDM)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma glucose. Timepoint: twice a week. Method of measurement: laboratory (mg/dl). | — |
Secondary
| Measure | Time frame |
|---|---|
| Preeclampsia. Timepoint: Antenatal and postpartum. Method of measurement: blood pressure (mmhg),proteinuria (mg/dl).;Preterm delivery. Timepoint: postnatal. Method of measurement: gestational age (week).;Cesarean section. Timepoint: tim of delivery. Method of measurement: mode of delivery.;Perinatal mortality. Timepoint: antenatal,neonatal period. Method of measurement: IUFD,Still birth,neonatal death.;Macrosomia. Timepoint: birth time. Method of measurement: birth weight(kg).;Hypoglycemia. Timepoint: 1st 24hr after birth. Method of measurement: laboratory (mg/dl).;NICU admission. Timepoint: neonatal period. Method of measurement: day. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Azin Alavi
Tehran University of Medical Sciences
Outcome results
None listed