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Effect of curcumin mouthwash on incidence of Ventilator-Associated Pneumonia in hospitalized patient in critical care unit

Investigating the effect of curcumin mouthwash on the incidence of ventilator-associated pneumonia in patients admitted to the intensive care unit

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20110427006318N16
Enrollment
30
Registered
2025-06-04
Start date
2025-06-15
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-Associated Pneumonia. J69.0 Pneumonitis due to food and vomit

Interventions

Intervention 1: Intervention group: In the intervention group, mouthwash by using curcumin solution 1%,, are doing twice a day in 8 am and 4 pm for 5 days. Intervention 2: Control group: In the contro

Sponsors

Semnan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients 18-75 years old Under mechanical ventilation for more than 48 hours Glasgow Coma scale between 6-11 Feeding with gastric tube No contraindications to oral care Curcumin insensitivity

Exclusion criteria

Exclusion criteria: Invasive procedure on the mouth and pharynx Re-intubation Tracheotomy Jaw and facial trauma Weakness of the immune system

Design outcomes

Primary

MeasureTime frame
Ventilator-Associated Pneumonia. Timepoint: 1th; 3th; and 5th days. Method of measurement: The assessment tool of ventilator-associated pneumonia modified clinical pulmonary infection score, which according to the body temperature, the white blood cell count, tracheal secretions, Ratio of arterial oxygen pressure (Pao2) to inspired oxygen fraction (Fio2) and chest x ray diagnose pneumonia.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMonir Nobahar

Semnan University of Medical Sciences

nobahar43@semums.ac.ir+98 23 3365 4190

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026