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The effect of progesterone supplementation on pregnancy rates in controlled ovarian stimulation and intrauterine insemination cycles: a randomized prospective trial

The effect of progesterone supplementation on pregnancy rates in controlled ovarian stimulation and intrauterine insemination cycles: a randomized prospective trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201104266292N1
Enrollment
300
Registered
2011-05-31
Start date
2009-10-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Female infertility, unspecified. Condition 2: Male infertility. inability to achieve a pregnancy Azoospermia NOS

Interventions

Intervention 1: Intervention: application of progesterone 400 mg vaginal suppository Cyclogest once daily from the day of IUI until negative beta HCG or 12 week. Intervention 2: Controi: no drug.
Treatment - Drugs
Intervention: application of progesterone 400 mg vaginal suppository Cyclogest once daily from the day of IUI until negative beta HCG or 12 week
Controi: no drug

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: All women included in the study were between the age 18 and 35 years and BMI of 18-28 kg/m2, regular mense, and no PCOD (according to Rotterdam criteria), basal FSH10 IU/mL, presence of resistant ovarian cyst (>20mm for > 1 months), hypogonadotrophic hypogonadism or any contraindications for progesterone therapy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy rate. Timepoint: 4 weeks after insemination. Method of measurement: Transvaginal sonography.

Secondary

MeasureTime frame
Ovulation rate. Timepoint: The days 12, 14 cycles. Method of measurement: Transvaginal sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahboobeh Rahmani

Tehran University of Medical Science, Shariati Hospital

rahmani@razi.tums.ac.ir+98 21 8800 8810

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026