Determination of time and amount of hyper tonic saline required to induce a 15% FEV1 decrease in asthmatic patients referred to shahid beheshti hospita,l Kashan

Determination of time and amount of hyper tonic saline required to induce a 15% FEV1decrease in asthmatic patients with FEV1>60% predicted

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201104266187N2

Enrollment

Registered

2011-07-18

Start date

2011-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma. Mixed asthma

Interventions

Intervention: The patients will be exposed to ultrasonic nebulizer with stable amount of nebulized hypertonic saline in 0.5, 1, 2, 4 and 8 minutes. The nebulization will be continued till a 15% decrea

Treatment - Drugs

Eligibility

Sex/Gender

All

Age

15 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: asthmatic patients, age between 15 to 60 with FEV1>60% Exclusion criteria: pneumonia; bronchectasia, advance interstitial lung disease; pulmonary fibrosis; chronic obstructive pulmonary disease and valvular & congenital heart disease.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
15% decrease in FEV1. Timepoint: 0.5 minute. Method of measurement: Spirometry.;15%decrease in FEV1. Timepoint: 1 minute. Method of measurement: spirometry.;15% decrease in FEV1. Timepoint: 2 minute. Method of measurement: spirometry.;15% decrease in FEV1. Timepoint: 4 minute. Method of measurement: spirometry.;15% decrease in FEV1. Timepoint: 6 minute. Method of measurement: spirometry.;15% decrease in FEV1. Timepoint: 8 minute. Method of measurement: spirometry.	—

Measure

Time frame

15% decrease in FEV1. Timepoint: 0.5 minute. Method of measurement: Spirometry.;15%decrease in FEV1. Timepoint: 1 minute. Method of measurement: spirometry.;15% decrease in FEV1. Timepoint: 2 minute. Method of measurement: spirometry.;15% decrease in FEV1. Timepoint: 4 minute. Method of measurement: spirometry.;15% decrease in FEV1. Timepoint: 6 minute. Method of measurement: spirometry.;15% decrease in FEV1. Timepoint: 8 minute. Method of measurement: spirometry.

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Secondary

Measure	Time frame
20% decrease in PEF. Timepoint: 0.5 minute. Method of measurement: spirometry.;20% decrease in PEF. Timepoint: 1 minute. Method of measurement: spirometry.;20% decrease in PEF. Timepoint: 2 minute. Method of measurement: spirometry.;20% decrease in PEF. Timepoint: 4 minute. Method of measurement: spirometry.;20% decrease in PEF. Timepoint: 6 minute. Method of measurement: spirometry.;20% decrease in PEF. Timepoint: 8 minute. Method of measurement: spirometry.	—

Measure

Time frame

20% decrease in PEF. Timepoint: 0.5 minute. Method of measurement: spirometry.;20% decrease in PEF. Timepoint: 1 minute. Method of measurement: spirometry.;20% decrease in PEF. Timepoint: 2 minute. Method of measurement: spirometry.;20% decrease in PEF. Timepoint: 4 minute. Method of measurement: spirometry.;20% decrease in PEF. Timepoint: 6 minute. Method of measurement: spirometry.;20% decrease in PEF. Timepoint: 8 minute. Method of measurement: spirometry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammad ali saba

Kashan University of Medicine Sciences

saba-ma@kaums.ac.ir+98 36 1555 0026

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026