Therapeutic effects of hyalase injection on lumbar spinal canal stenosis

Evaluation of the effects of hyalase injection into hypertrophic ligamentum flovum on clinical symptoms and MRI findings in lumbar spinal canal stenosis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110420006239N3

Enrollment

Registered

2020-11-05

Start date

2020-10-13

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lumbar Canal Stenosis secondary to Hypertrophic Ligamentum Flovum. Spinal stenosis, lumbar region

Interventions

Intervention 1: Intervention group: a mixture of Hyalase 1500u and 40mg methylprednisolone injected into the ligamentum flavum. Intervention 2: Intervention group: a mixture of Hyalase 1500u and 40mg

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Persistent Low Back Pain Lumbar Canal Stenosis Hypertrophy of Ligamentum Flovum Inefficacy of Conservative therapies Age over 18

Exclusion criteria

Exclusion criteria: Laminectomy Surgery Coagulopathy Dermal Infection near the site of injection Presence of SOL in Spinal Cord Ossification and Calcification Pregnancy

Design outcomes

Secondary

Measure	Time frame
Imaging findings. Timepoint: Before injection and then one week after injection. Method of measurement: MRI findings due to Severity of Lumbar Canal Stenosis.	—

Primary

Measure	Time frame
Pain intensity. Timepoint: Before injection and then one week after injection. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDawood Aghamohamadi

Tabriz University of Medical Sciences

daghamohamadi@yahoo.com+98 41 3334 1994

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026