The effect of Nifedipine for treatment of anal fissure

Comparison of topical Nifedipine with oral Nifedipine for treatment of anal fissure: A randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201104166200N1

Enrollment

119

Registered

2012-11-16

Start date

2002-02-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic anal fissure. Chronic anal fissure

Interventions

Intervention 1: Nifedipine cream (0.5%) for 4 weeks. Intervention 2: 10 mg of Nifedipine TDS for 4 weeks.

Treatment - Drugs

Nifedipine cream (0.5%) for 4 weeks

10 mg of Nifedipine TDS for 4 weeks

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: chronic anal fissure patients. Exclusion criteria: patients had history of sexually transmitted disease, TB, IBD, or medically related conditions such as gestation, migraine, cardiovascular and other chronic diseases, anorectal surgery or another anorectal disease.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Ulcer healing in anal fissure. Timepoint: 4 weeks (traetment period), 6 months (follow up). Method of measurement: visual score.	—

Secondary

Measure	Time frame
Headache. Timepoint: 2 months, 6 months. Method of measurement: visual, patient ducument.;Blood pressure and pulse rate. Timepoint: 2 months, 6 months. Method of measurement: sphygnomanometer, physical exam, patient ducument.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzaneh Golfam

Shahed university

golfam@shahed.ac.ir+98 21 8896 9437

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026