stress ulcer. Gastric ulcer
Conditions
Interventions
Intervention 1: In intervention group Pantoprazol 40 mg once a day will infuse till to end of patient admission. Intervention 2: In control group Ranitidine 50 mg twice a day will infuse till to end
Prevention
In intervention group Pantoprazol 40 mg once a day will infuse till to end of patient admission.
In control group Ranitidine 50 mg twice a day will infuse till to end of patient admission.
Sponsors
Hamedan University of Medical Sciences-vice chancellor for research
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients who required mechanical ventilation, Age more than 18 years old, Admission to the ICU, APACHE SCORE II less than 25, Admission at least 24 hour in ICU, Patients with suctionable secretion, No GI bleeding at the beginning of study Exclusion criteria: History of GI bleeding, liver or kidney insufficiency, History of corticosteroids or NSAIDs usage, Gastric PH more than 4 before beginning of prophylaxis
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastric PH. Timepoint: Before intervention, every 8 houres after intervention for two next days. Method of measurement: The level of gastric PH which is measured by AZ8685 PH metery instrument. | — |
Secondary
| Measure | Time frame |
|---|---|
| GI bleeding. Timepoint: Daily. Method of measurement: Evaluating the secretion which lavaged from the patient NG tube to the end of admission in the ICU. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed