Comparison of oral misoprostol and Intravenous oxytocin for induction of labor at Premature rupture of membrane in primigravida women

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201104131946N9

Enrollment

240

Registered

2011-08-21

Start date

2011-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy, childbirth and the puerperium. Other complications of anaesthesia during labour and delivery

Interventions

Intervention 1: Prescription of 75 microgram of oral Misoprostol plus intra venous normal saline. Intervention 2: Prescription of intra venous oxytocin 2mlu/min increased 2 mlu/min any 10 minute.

Treatment - Drugs

Prescription of 75 microgram of oral Misoprostol plus intra venous normal saline

Prescription of intra venous oxytocin 2mlu/min increased 2 mlu/min any 10 minute.

Eligibility

Sex/Gender

Male

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: a) single pregnancy (between 36 to 42 weeks); b)vertex presentation; c)bishop score equal or less than four; d) absence of uterus spontaneous contractions;e)normal fetal heart rate; f) cephalopelvic proportion. Exclusion criteria: a) sensitivity to PGs; b) previous history of cesarean; c) uterus wall scar; d) preeclampsia or blood pressure more than 140/90 mmHg; e) history of heart disease ,asthma, glaucoma; f)IUGR; g)age under18 years

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Comparison of oral misoprostol and Intravenous oxytocin. Timepoint: Every four hours up to two times. Method of measurement: Vaginal examination and record in Questionnaire.	—

Secondary

Measure	Time frame
Determination of time interval from labor induction beginning to active phase reaching. Timepoint: Time recording of induction beginning and delivery. Method of measurement: Time recording of induction beginning and delivery in Questionnaire.;Delivery type frequency. Timepoint: After delivery. Method of measurement: Patients' medical document.;Vaginal delivery frequency during first 12 hours. Timepoint: After delivery. Method of measurement: Patients' medical document.;Tachysystole incidence. Timepoint: Time recording of induction beginning up to active phase. Method of measurement: Patients' medical document.;Hyper stimulation incidence. Timepoint: Time recording of induction beginning up to active phase. Method of measurement: Patients' medical document.;Fetal Heart Rate disorder. Timepoint: Time recording of induction beginning and delivery. Method of measurement: Patients' medical document.;Failure to progress frequency. Timepoint: Entering to active phase up to delivery. Method of measurement: Patients' medical document.;Determination of Bishop Score alteration average after 4 hours. Timepoint: After 4 hours from induction beginning. Method of measurement: Vaginal examination.;Determination of NICU admission rate. Timepoint: After delivery. Method of measurement: Patients' medical document.;APGAR score less than 7. Timepoint: After delivery. Method of measurement: Patients' medical document.;Frequency of maternal complication. Timepoint: Time recording of induction beginning and delivery. Method of measurement: Patients' medical document.	—

Measure

Time frame

Determination of time interval from labor induction beginning to active phase reaching. Timepoint: Time recording of induction beginning and delivery. Method of measurement: Time recording of induction beginning and delivery in Questionnaire.;Delivery type frequency. Timepoint: After delivery. Method of measurement: Patients' medical document.;Vaginal delivery frequency during first 12 hours. Timepoint: After delivery. Method of measurement: Patients' medical document.;Tachysystole incidence. Timepoint: Time recording of induction beginning up to active phase. Method of measurement: Patients' medical document.;Hyper stimulation incidence. Timepoint: Time recording of induction beginning up to active phase. Method of measurement: Patients' medical document.;Fetal Heart Rate disorder. Timepoint: Time recording of induction beginning and delivery. Method of measurement: Patients' medical document.;Failure to progress frequency. Timepoint: Entering to active phase up to delivery. Method of measurement: Patients' medical document.;Determination of Bishop Score alteration average after 4 hours. Timepoint: After 4 hours from induction beginning. Method of measurement: Vaginal examination.;Determination of NICU admission rate. Timepoint: After delivery. Method of measurement: Patients' medical document.;APGAR score less than 7. Timepoint: After delivery. Method of measurement: Patients' medical document.;Frequency of maternal complication. Timepoint: Time recording of induction beginning and delivery. Method of measurement: Patients' medical document.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mandana Mansur Ghanaie

Guilan University of Medical Sciences

m_m_ghanaie@yahoo.com+98 13 1322 5624

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026