Retrograde amnesia for unpleasant events in the perioperative period. Reaction to severe stress, and adjustment disorders
Conditions
Interventions
Intervention 1: Control group: There are 50 patients in control group that receive placebo (water) intravenously. Drugs or placebo are prepared in identical syringes and are randomly administered dur
Placebo
Treatment - Drugs
Control group: There are 50 patients in control group that receive placebo (water) intravenously. Drugs or placebo are prepared in identical syringes and are randomly administered during a period of
Intervention group 1: In the recovery room, immediately after visual, sensory and auditory stimuli, the first intervention group (50 patients) receive intravenous ketamine 0.3 mg/kg in addition to di
Intervention group 2: In the recovery room, immediately after visual, sensory and auditory stimuli, the second intervention group (50 patients) receive intravenous ketamine 0.5 mg/kg in addition to d
Sponsors
Ahvaz Judishapur university of medical sciences
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Patients aged 18 to 35 years (ASA CLASS I) undergoing surgery and general anesthesia are included in this study. Patients that should not receive ketamine because of intracranial mass, increased intracranial pressure, head trauma, open globe injuries, ischemic heart disease, vascular aneurisms, psychological disorders, and history of adverse reactions to ketamine are excluded from this study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recall of the sensory stimuli. Timepoint: Before administration of drugs or placebo in the postanesthesia care unit (PACU), before discharge from PACU and also 10 hours after discharge. Method of measurement: Questionnaire.;Recall of the visual stimuli. Timepoint: Before administration of drugs or placebo in the postanesthesia care unit (PACU), before discharge from PACU and also 10 hours after discharge. Method of measurement: Questionnaire.;Recall of the auditory stimuli. Timepoint: Before administration of drugs or placebo in the postanesthesia care unit (PACU), before discharge from PACU and also 10 hours after discharge. Method of measurement: Questionnaire.;Recall of the surgery day events. Timepoint: Before administration of drugs or placebo in the postanesthesia care unit (PACU), before discharge from PACU and also 10 hours after discharge. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactEhsan Farazi
Ahvaz Judishapur university of medical sciences
Outcome results
None listed