Effect of dexamethasone on reduction of pain after cesarean section.

Comparative evaluation of effect of IV Dexamethasone on post-cesarean pain

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201104095934N2

Enrollment

Registered

2012-07-21

Start date

2010-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after celective cesarean. Delivery by elective caesarean section

Interventions

Intervention 1: we administer 8 mg of IV dexamethasone to case group. Intervention 2: the control group receive 2 cc normal saline at the same time.

Treatment - Drugs

Placebo

we administer 8 mg of IV dexamethasone to case group

the control group receive 2 cc normal saline at the same time

Eligibility

Sex/Gender

Female

Age

18 Years to 34 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: healthy pregnant, single baby and full term (G1) women who were candidated for elective cesarean in Beheshti hospital. Exclusion criteria: any sensitivity or allergy to glucocorticoids; present or past history of PUD( peptic ulcer disease), glaucoma, DM( Diabete Mellitus ) 1,2, heart failure, fungal or viral systemic infection, HTN ( Hypertention ) or any other poor-controlled disease.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Effect of IV Dexamethasone on post-cesarean pain. Timepoint: At at time of 0, 15, 30, 60 min and 2, 4, 6, 12, 18, 24 hours after CS. Method of measurement: Severity of pain and vomiting ( base on VAS) was measured by giving a 10cm ruler to the patients .VAS ( Visual Analogue Scale ) is a method of pain evaluation by using a 10cm.in this method, the patient will be asked to indicate zero in case of having no pain and ten in case of having the most sever pain.;Effect of IV dexamethasone on reduction of morphine consumption after cesarean section. Timepoint: All the patients receive one routine dose of morphine at recovery room and then if need with intervals of 4 hours. Morphin consomption rate is recorded and in the end will be evaluated. Method of measurement: Results which are recorded based on miligrams.;Effect of IV Dexamethasone on reduction of vomiting and methoclopramide consumption after cesarean section. Timepoint: Monitored at time of 0, 15, 30, 60 min and 2, 4, 6, 12, 18, 24 hours after CS. Method of measurement: Severity of pain and vomiting ( base on VAS) is measured by giving a 10cm ruler to the patients .VAS ( Visual Analogue Scale ) is a method of pain and vomiting evaluation by using a 10cm.in this method, the patient will be asked to indicate zero in case of having no vomiting and ten in case of having the most sever vomiting. we considered VAS score 1-3 as mild,4-7 as moderate and 7-10 as sever.Rescue antiemetic (methoclopramide 10 mg, ) was given if vomiting occurrs or at parturients request. treatment is repeated if necessary.and total dose of methoclopramide will be recorded.	—

Measure

Time frame

Effect of IV Dexamethasone on post-cesarean pain. Timepoint: At at time of 0, 15, 30, 60 min and 2, 4, 6, 12, 18, 24 hours after CS. Method of measurement: Severity of pain and vomiting ( base on VAS) was measured by giving a 10cm ruler to the patients .VAS ( Visual Analogue Scale ) is a method of pain evaluation by using a 10cm.in this method, the patient will be asked to indicate zero in case of having no pain and ten in case of having the most sever pain.;Effect of IV dexamethasone on reduction of morphine consumption after cesarean section. Timepoint: All the patients receive one routine dose of morphine at recovery room and then if need with intervals of 4 hours. Morphin consomption rate is recorded and in the end will be evaluated. Method of measurement: Results which are recorded based on miligrams.;Effect of IV Dexamethasone on reduction of vomiting and methoclopramide consumption after cesarean section. Timepoint: Monitored at time of 0, 15, 30, 60 min and 2, 4, 6, 12, 18, 24 hours after CS. Method of measurement: Severity of pain and vomiting ( base on VAS) is measured by giving a 10cm ruler to the patients .VAS ( Visual Analogue Scale ) is a method of pain and vomiting evaluation by using a 10cm.in this method, the patient will be asked to indicate zero in case of having no vomiting and ten in case of having the most sever vomiting. we considered VAS score 1-3 as mild,4-7 as moderate and 7-10 as sever.Rescue antiemetic (methoclopramide 10 mg, ) was given if vomiting occurrs or at parturients request. treatment is repeated if necessary.and total dose of methoclopramide will be recorded.

—

Secondary

Measure	Time frame
Effect of IV dexamethasone on vital sign ( MAP ( mean arterial pressure),HR ( heart rate ),RR( respiratory rate ). Timepoint: At times of 0, 15, 30, 60 min and 2, 4, 6, 12, 18, 24 hours after CS. Method of measurement: By using a sphigmomanometer for blood pressure and a digital watch for RR and HR.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShadi Nouri

Medicine college, Isfahan University of Medical Sciences

babaei@edc.mui.ac.ir+98 31 1788 3314

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026