ketamine role in depression treatment

Comparison the effect of electroconvulsive therapy and intravenous infusion of ketamine on control and relapse of depressive symptoms in depressive cases who are candidate of electro convulsive therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201104092266N2

Enrollment

Registered

2011-06-08

Start date

2011-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depression.

Interventions

Intervention 1: Intervention group:receives 3time/ week slow infusion of 0.5mg/kg ketamine until complete symptom remission with direct supervision of an anesthesiologist. Intervention 2: Control grou

Treatment - Drugs

Treatment - Other

Intervention group:receives 3time/ week slow infusion of 0.5mg/kg ketamine until complete symptom remission with direct supervision of an anesthesiologist

Control group: receives 3 time/week bi-temporal ECT until complete symptom remission by a psychiatrist and anesthesiologist

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: IInclusion Criteria: Known case of major depressive disorder without psychotic feature based on DSM IV-TR who Referred to ECT by a psychiatrist; age between 20-50 years; signing the consent form. Exclusion Criteria: History of psychosis or being psychotic; substance abuse during recent 3 months; breast feeding mothers; having medical incapacitating disease such as: renal, hepatic, gastro intestinal, cardiovascular, endocrine, neurologic and hematologic disease based on history and clinical and Para clinical evaluations; history of seizure with unknown origin; uncontrolled hypo or hyper thyroidism ; simultaneous another psychiatric interventions

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Severity of major depressive symptoms. Timepoint: prior to each intervention session, one week, 1,2 and 3 month afer intervention. Method of measurement: structured interviewe based on Hamilton Depressive Rating Scale.	—

Secondary

Measure	Time frame
Cognitive Side effects. Timepoint: Prior to intervention, one week and one month after intervention. Method of measurement: Adult Wechsler Memory Scal.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Gholam Reza Kheirabadi

Behavioral Sciences Research Center, Isfahan University of Medical Sciences

kheirabadi@bsrc.mui.ac.ir+98 31 1222 2135

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026