End stage of renal disease (hemodialysis). Chronic renal failure
Conditions
Interventions
Intervention 1: alpha-lipoic acid intake ,600mg per day, for 2 months. Intervention 2: Vitamin E intake, 400IU per day ,for 2 months. Intervention 3: alph-lipoic acid 600mg+VitaminE400IU, per day,for
Treatment - Drugs
Placebo
alpha-lipoic acid intake ,600mg per day, for 2 months
Vitamin E intake, 400IU per day ,for 2 months
alph-lipoic acid 600mg+VitaminE400IU, per day,for 2 months
placebo intake for 2 months
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age 20-60 years, hemodialysis, twice a week, undergoing maintenance hemodialysis for more than 1 year, no receiving antioxidant supplements such as VitE, VitC, or fish oil Exclusion criteria: smoking, pregnancy, presence of acute inflammatory and infectious diseases, presence of liver or Rheumatic diseases (such as lupus,...), cardiac diseases, or cancer, use of anticoagulants or contraceptives thyroxin
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hs-CRP. Timepoint: Before and 2 months after intervention. Method of measurement: ELISA kit.;Malon-dialdehide (MDA). Timepoint: Before and 2 months after intervention. Method of measurement: Spectrophotometry.;Interlukin-6 (IL6). Timepoint: Before and 2 months after intervention. Method of measurement: RIA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin. Timepoint: Before and 2 months after intervention. Method of measurement: ELISA kit.;Lipid profile. Timepoint: Before and 2 months after intervention. Method of measurement: Auto analyser.;FBS. Timepoint: Before and 2 months after intervention. Method of measurement: Auto analyser. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNegin Mazouji
School of Health And Nutrition, Shiraz University of Mediccal Sciences
Outcome results
None listed