Preload versus coload of ringer lactate to prevent hypotension during elective cesarean section under spinal anesthesia

Comparison of preload and coload of ringer lactate to prevent hypotension during elective cesarean section under spinal anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110313006044N5

Enrollment

Registered

2022-03-25

Start date

2022-01-21

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension during cesarean section. Hypotension

Interventions

Intervention 1: Intervention group: Patients in the preload group will receive 10 ml/kg Ringer’s solution (Samen Pharmaceutical Co., Mashhad, Iran) within 15 min before the blockade. Intervention 2: I

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age 18-45 years Singleton term pregnancy Elective cesarean section Spinal anesthesia American Society of Anesthesiologists (ASA) class I or II

Exclusion criteria

Exclusion criteria: Twin or multiple pregnancy ASA class above II Hypertension or cardiovascular diseases Contraindications of spinal anesthesia Hypersensitivity to bupivacaine Renal disorders Severe hemorrhage during surgery requiring blood transfusion Uterine atony requiring hysterectomy Block failure or incomplete block demanding extra anesthetics

Design outcomes

Primary

Measure	Time frame
Maternal blood pressure. Timepoint: Baseline, immediately after spinal anesthesia, then at 2, 4, 6, 8, 10, 15, 20, 25, 30, 40, 50, and 60 min after spinal anesthesia and in the recovery unit. Method of measurement: Monitoring device.	—

Secondary

Measure	Time frame
Maternal mean arterial pressure. Timepoint: Baseline, immediately after spinal anesthesia, then at 2, 4, 6, 8, 10, 15, 20, 25, 30, 40, 50, and 60 min after spinal anesthesia and in the recovery unit. Method of measurement: Monitoring device.;Maternal heart rate. Timepoint: Baseline, immediately after spinal anesthesia, then at 2, 4, 6, 8, 10, 15, 20, 25, 30, 40, 50, and 60 min after spinal anesthesia and in the recovery unit. Method of measurement: Monitoring device.;Maternal oxygen saturation. Timepoint: Baseline, immediately after spinal anesthesia, then at 2, 4, 6, 8, 10, 15, 20, 25, 30, 40, 50, and 60 min after spinal anesthesia and in the recovery unit. Method of measurement: Monitoring device.;Neonatal Apgar score. Timepoint: 1 and 5 min after delivery. Method of measurement: Clinical assessment.	—

Measure

Time frame

Maternal mean arterial pressure. Timepoint: Baseline, immediately after spinal anesthesia, then at 2, 4, 6, 8, 10, 15, 20, 25, 30, 40, 50, and 60 min after spinal anesthesia and in the recovery unit. Method of measurement: Monitoring device.;Maternal heart rate. Timepoint: Baseline, immediately after spinal anesthesia, then at 2, 4, 6, 8, 10, 15, 20, 25, 30, 40, 50, and 60 min after spinal anesthesia and in the recovery unit. Method of measurement: Monitoring device.;Maternal oxygen saturation. Timepoint: Baseline, immediately after spinal anesthesia, then at 2, 4, 6, 8, 10, 15, 20, 25, 30, 40, 50, and 60 min after spinal anesthesia and in the recovery unit. Method of measurement: Monitoring device.;Neonatal Apgar score. Timepoint: 1 and 5 min after delivery. Method of measurement: Clinical assessment.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHashem Jarineshin

Bandare-abbas University of Medical Sciences

hjarineshin@yahoo.com+98 76 3334 5009

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026