Hemodynamic Change. Postprocedural disorder of circulatory system, unspecified
Conditions
Interventions
Treatment - Drugs
Intervention 1: Control group: Normal saline + 0.3 mg/kg Etomidate. Intervention 2: Intervention group 1 : 0.5 mg/kg Ketamine + 1.5 mg/kg Propofol. Intervention 3: Intervention group 2 : 0.5 mg/kg Ket
Control group: Normal saline + 0.3 mg/kg Etomidate
Intervention group 1 : 0.5 mg/kg Ketamine + 1.5 mg/kg Propofol
Intervention group 2 : 0.5 mg/kg Ketamine + 3 mg/kg thiopental Na
Sponsors
Vice chancellor for research of Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Informed written consent; ASA class ?-??; Age between 18 and 45 years; Elective surgery Exclusion criteria: Adrenal insufficiency; Received etomidate or propofol or thiopental in one week ago; Receiving steroids at 6 months ago; Sensitivity to etomidate or propofol or thiopental; Egg and soy allergy; Sepsis; endocarditis; Chronic inflammatory diseases; Any severe disease and seriously endocrine, neurological, Psychiatric and Metabolic disorders; Pregnant or lactating women; Need for rapid intubation in emergency patients; Asthma; HIV infection; History of hypertension; Taking beta blocker, calcium blockers and angiotensin II inhibitors.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic blood pressure. Timepoint: 1 min after administration of hypnotic drugs just before laryngoscopy as well as 1 and 3 min after laryngoscopy and tracheal intubation. Method of measurement: Automated sphygmomanometer.;Diastolic blood pressure. Timepoint: 1 min after administration of hypnotic drugs just before laryngoscopy as well as 1 and 3 min after laryngoscopy and tracheal intubation. Method of measurement: automated sphygmomanometer.;Mean arterial pressure. Timepoint: 1 min after administration of hypnotic drugs just before laryngoscopy as well as 1 and 3 min after laryngoscopy and tracheal intubation. Method of measurement: automated sphygmomanometer.;Heart rate. Timepoint: 1 min after administration of hypnotic drugs just before laryngoscopy as well as 1 and 3 min after laryngoscopy and tracheal intubation. Method of measurement: Heart monitoring. | — |
Secondary
| Measure | Time frame |
|---|---|
| Delirium. Timepoint: After anesthesia. Method of measurement: Inspection.;Nausea and vomiting. Timepoint: After anesthesia. Method of measurement: Inspection.;Twitching. Timepoint: After anesthetic infusion. Method of measurement: Inspection.;Pain. Timepoint: After anesthetic infusion. Method of measurement: Inspection. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfshin Gholipour Baradari MD
Mazandaran University Of Medical Sciences
Outcome results
None listed