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Evaluating the effectiveness and safety of rosemary (Rosmarinus officinalis L.) on cognitive impairments, and positive and negative symptoms in patients with chronic schizophrenia: double blind placebo-controlled randomized trial

Evaluating the effectiveness and safety of rosemary (Rosmarinus officinalis L.) on cognitive impairments, and positive and negative symptoms in patients with chronic schizophrenia: double blind placebo-controlled randomized trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20110310006026N13
Enrollment
50
Registered
2024-04-17
Start date
2024-04-20
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic schizophrenia. Schizophrenia

Interventions

Intervention 1: Intervention group: Powdered rosemary is administered as one 750 mg capsule twice daily for four weeks. Intervention 2: Control group: starch as placebo (in control group) is administe

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Hospitalized patients with chronic schizophrenia (6 months or more should be passed from illness commencement) based on DSM-V criteria Having no significant change in medication or symptoms over the previous 2 months

Exclusion criteria

Exclusion criteria: Mental retardation Substance dependence History of significant medical illness Alterations in the received medications Hypersensitivity reactions to rosemary

Design outcomes

Primary

MeasureTime frame
Cognitive functions. Timepoint: At baseline and 4 weeks after intervention. Method of measurement: Screen for Cognitive Impairment in Psychiatry (SCIP) questionnaire.;Positive and negative symptoms. Timepoint: At baseline and 4 weeks after intervention. Method of measurement: Positive and Negative Syndrome Scale (PANSS) questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Dabaghzadeh

Kerman University of Medical Sciences

fatemeh.dabaghzadeh@gmail.com+98 34 3132 5034

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026