Abnormal uterine bleeding. Other specified abnormal uterine and vaginal bleeding
Conditions
Interventions
Intervention 1: diphereline 3.75 mg IM every 28 days for 3 doses. Intervention 2: standard surgical treatment (abdominal hysterectomy).
Treatment - Drugs
Treatment - Surgery
diphereline 3.75 mg IM every 28 days for 3 doses
standard surgical treatment (abdominal hysterectomy)
Sponsors
Vice Chancellor for Research, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
40 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Premenopausal women between 40-55 years old with abnormal uterine bleeding for at least 2 months which is described as bleeding more than 7 days in a month or heavy bleeding resulting in anemia (Hct<32%), no evidence for atypical heperplasia or carcinoma in D&C, no response to simple medications such as medroxy progetrone and contraceptive tablets, no Ovarian or uterine organic lesions (ruled out by using clinical examination and ultrasonography) Exclusion criteria: Anemia for other reasons, Fertility preservation, Evidence of pregnancy, Endocrinopathy, Coagulopathy, contraindications for medical treatment, Using IUD
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Uterine bleeding. Timepoint: before intervention, 2, 3 months and 2 years after intervention. Method of measurement: asking from patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| Anemia. Timepoint: before intervention, 2, 3 months and 2 years after intervention. Method of measurement: Hb and Hct analysis.;Quality of life. Timepoint: before intervention, 2, 3 months and 2 years after intervention. Method of measurement: WHOOQL standard questionaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElaheh Ouladsahebmadarek
Tabriz University of Medical Sciences
Outcome results
None listed