Condition 1: Varicocele. Condition 2: Male infertility. Scrotal varices Male infertility
Conditions
Interventions
Intervention 1: The control group receives two daily doses of starch-filled capsules as placebo, for 3 months after the surgery. Intervention 2: The control group receives two daily doses of capsules
Placebo
Treatment - Drugs
The control group receives two daily doses of starch-filled capsules as placebo, for 3 months after the surgery.
The control group receives two daily doses of capsules filled with 500 mg of vitamin C (Osveh pharmaceuticals- Ref No. 1228038410) for 3 months after the surgery.
Sponsors
Vice chancellor for research, Arak University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Palpable varicocele (grade 2 or 3) in physical examination; Abnormality in count, motility, or morphology of sperm in two separate semen analyses based on WHO criteria; No azoospermia; No major underlying disease such as: diabetes or hormonal abnormalities based on history and physical examination; Not smoker or addicted to any recreational drugs; Not using any drugs or supplements on a regular basis; Age between 18-50 years; Weight between 50-100 kg; No active or chronic genitourinary infection based on history, physical examination, urine analysis, and semen analysis; No previous history of peptic ulcer disease or vitamin C intolerance Exclusion criteria: Patients' unwillingness to continue participation; Not attending follow up visits; Incorrect utilization of the capsules; Occurrence of side effects due to capsules; Late complications of surgery such as hydrocele, recurrence of varicocele, or testis atrophy; Commencement of smoking or addiction during the follow up
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sperm motility. Timepoint: Before and 3 months after the surgery. Method of measurement: Mean percent of motile sperm class A+B in two separate semen analyses.;Sperm count. Timepoint: Before and 3 months after the surgery. Method of measurement: Mean concentration of sperm in two separate semen analyses.;Sperm morphology. Timepoint: Before and 3 months after the surgery. Method of measurement: Mean percent of sperm with normal morphology based on WHO criteria in two separate semen analyses. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: During the 3-month period of follow up. Method of measurement: Bases on patients' report on monthly visits. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ali Cyrus
Arak University of Medical Sciences
Outcome results
None listed