The effect of Gonadotropin-Releasing Hormone (GnRH) antagonist pretreatment on the number of oocytes obtained from ovarian stimulation.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110301005942N10

Enrollment

Registered

2025-10-22

Start date

2025-11-01

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention group: Standard stimulation with Gonadotropin-Releasing Hormone (GnRH) antagonist will be used with the difference that a pretreatment consisting of GnRH antagonist administration will be

Eligibility

Sex/Gender

Female

Age

20 Years to 44 Years

Inclusion criteria

Inclusion criteria: Infertile women in the age range of 20 to 44 years Women receiving treatment with intracytoplasmic sperm injection (ICSI) Women who did not become pregnant after one standard ovarian stimulation cycle with a gonadotropin-releasing hormone (GnRH) antagonist (standard cycle) (before intervention).

Exclusion criteria

Exclusion criteria: Planned ovarian stimulation for purposes other than ICSI (such as preimplantation genetic diagnosis or genetic screening) Indications for oocyte donation Oocyte cryopreservation basal serum progesterone levels exceeding 1.5 ng/mL

Design outcomes

Primary

Measure	Time frame
Number of retrieved oocytes. Timepoint: The day of oocytes pick up. Method of measurement: Microscopic evaluation.;Quality of resulted oocytes. Timepoint: The day of oocytes pick up. Method of measurement: Microscopic evaluation.;Percentage of mature (MII) oocytes. Timepoint: The day of oocytes pick up. Method of measurement: Microscopic evaluation.;Fertilization rate. Timepoint: Fertilization assessment will be performed 16 to 18 hours after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Method of measurement: Microscopic evaluation.;Embryo quality. Timepoint: day 3 after fertilization. Method of measurement: Microscopic evaluation.	—

Measure

Time frame

Number of retrieved oocytes. Timepoint: The day of oocytes pick up. Method of measurement: Microscopic evaluation.;Quality of resulted oocytes. Timepoint: The day of oocytes pick up. Method of measurement: Microscopic evaluation.;Percentage of mature (MII) oocytes. Timepoint: The day of oocytes pick up. Method of measurement: Microscopic evaluation.;Fertilization rate. Timepoint: Fertilization assessment will be performed 16 to 18 hours after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Method of measurement: Microscopic evaluation.;Embryo quality. Timepoint: day 3 after fertilization. Method of measurement: Microscopic evaluation.

—

Secondary

Measure	Time frame
Distribution of oocyte maturation stages. Timepoint: day of oocyte pick up. Method of measurement: with microscope.;Oocyte morphological quality. Timepoint: day of oocyte pick up. Method of measurement: with microscope.;Proportion of high-quality embryos (Grade A). Timepoint: day 3 ????? ?????????????. Method of measurement: with microscope.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAliye Ghasemzadeh

Tabriz University of Medical Sciences

lahroudin@gmail.com+98 41 3553 9160

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026