Acute Myocardial Infarction. Acute Myocardial Infarction
Conditions
Interventions
Intervention 1: Intervention: NAC 600 mg BD for 3 days per oral. Intervention 2: Control: Placebo BD for 3 days per oral.
Prevention
Intervention: NAC 600 mg BD for 3 days per oral
Control: Placebo BD for 3 days per oral
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria; Patients with criteria of first episode of ST-elevation AMI including typical chest pain with the duration of more than 30 minutes, >1-mm ST elevation in =2 adjacent limb leads or >2-mm ST elevation in =2 adjacent chest leads, and a raise in creatine kinase or in troponin T level 2 times the upper limit of normal were included in the study. Exclusion Criteria; Patients with history of prior AMI, heart failure, atrial fibrillation, valvular dysfunction, and neoplastic, renal, liver, or thyroid diseases were excluded from the study. Moreover patients with current acute or chronic infections, autoimmune diseases, surgical procedures in the past 3 months; under treatment with anti-inflammatory drugs, supplements and antioxidants, subsequent MI, discharge or death during the study period were excluded.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor necrosis factor-alpha. Timepoint: 24 and 72 hours after administration of NAC or Placebo. Method of measurement: Elisa.;Transforming growth factor-beta. Timepoint: 24 and 72 hours after administration of NAC or Placebo. Method of measurement: Elisa. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed