Maternal and neonatal effects of remifentanil in general anaesthesia for Caesarean delivery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201102252963N2

Enrollment

Registered

2011-04-16

Start date

2009-04-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Remifentanil. Opioids and related analgesics

Interventions

Intervention 1: An intravenous bolus of 0.5 µg/kg remifentanil immediately before induction of anesthesia. Intervention 2: The same volume of saline as remifentanil, intravenously, as placebo, immedia

Treatment - Drugs

Placebo

An intravenous bolus of 0.5 µg/kg remifentanil immediately before induction of anesthesia

The same volume of saline as remifentanil, intravenously, as placebo, immediately before induction of anesthesia

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: women with American Society of Anesthesia (ASA) physical status I or II and singleton term pregnancies who are candidate for cesarean section that is not emergent Exclusion criteria: Anaphylaxis reaction to the anesthetic drugs, excessive bleeding during the operation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Diastolic blood pressure. Timepoint: before of induction of general anesthesia,immediately after laryngoscopy and intubation, after incision of skin, after delivery of fetus. Method of measurement: NIBP monitoring.;Systolic blood pressures. Timepoint: before of induction of general anesthesia,immediately after laryngoscopy and intubation, after incision of skin, after delivery of fetus. Method of measurement: NIBP monitoring.;Mean arterial pressure. Timepoint: before of induction of general anesthesia,immediately after laryngoscopy and intubation, after incision of skin, after delivery of fetus. Method of measurement: NIBP monitoring.;Heart rate in mother. Timepoint: before of induction of general anesthesia,immediately after laryngoscopy and intubation, after incision of skin, after delivery of fetus. Method of measurement: EKG monitoring.	—

Measure

Time frame

Diastolic blood pressure. Timepoint: before of induction of general anesthesia,immediately after laryngoscopy and intubation, after incision of skin, after delivery of fetus. Method of measurement: NIBP monitoring.;Systolic blood pressures. Timepoint: before of induction of general anesthesia,immediately after laryngoscopy and intubation, after incision of skin, after delivery of fetus. Method of measurement: NIBP monitoring.;Mean arterial pressure. Timepoint: before of induction of general anesthesia,immediately after laryngoscopy and intubation, after incision of skin, after delivery of fetus. Method of measurement: NIBP monitoring.;Heart rate in mother. Timepoint: before of induction of general anesthesia,immediately after laryngoscopy and intubation, after incision of skin, after delivery of fetus. Method of measurement: EKG monitoring.

—

Secondary

Measure	Time frame
APGAR score in the neonate. Timepoint: 1 and 5 minutes after birth. Method of measurement: APGAR score.;Umblical cord PH. Timepoint: After delivery. Method of measurement: blood gas analysis.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShekoufeh Behdad

Shahid Sadoughi University of Medical Sciences

drbehdad@yahoo.com+98 35 1822 4104

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026