An evaluation of the effect of chlorhexidine in combination with sodium perborate on gingivitis, plaque and tooth surface staining

An in vitro/in vivo evaluation of the effect of chlorhexidine in combination with sodium perborate on gingivitis, plaque and tooth surface staining

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201102245900N1

Enrollment

Registered

2011-04-14

Start date

2010-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: gingivitis. Condition 2: tooth surface staining. Chronic gingivitis Posteruptive colour changes of dental hard tissues

Interventions

Intervention 1: Intervention in experimental group: 0.2% chlorhexidine gluconate mouthwash containing 0.2% sodium perborate. Intervention 2: Intervention in control group: 0.2% chlorhexidine gluconate

Treatment - Drugs

Intervention in experimental group: 0.2% chlorhexidine gluconate mouthwash containing 0.2% sodium perborate

Intervention in control group: 0.2% chlorhexidine gluconate mouthwash

Eligibility

Sex/Gender

All

Age

20 Years to 30 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Presence of at least 12 anterior teeth; Mild-to-moderate gingivitis, no pockets, no attachment loss; Informed written consent form. Exclusion criteria: allergic reaction to chlorhexidine; smoking habits; history of antibiotic use in the past three months; pregnancy; movable or fixed orthodontic appliances or movable prostheses; irremovable staining (due to tetracycline or fluoride).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Staining. Timepoint: After two weeks. Method of measurement: staining index designed by Lobene.	—

Secondary

Measure	Time frame
Gingivitis + plaque. Timepoint: After two weeks. Method of measurement: plaque indexes (PI), gingival indexes (GI) and bleeding indexes (BI).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Zarandi

Hamedan dental faculty

zarandi.ali@umsha.ac.ir+98 81 1825 0498

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026