Endometriosis.
Conditions
Interventions
Intervention 1: Intervention group: 30 mg pioglitazone daily for 6 months. Intervention 2: Control group: OCP (LD) one pill daily for 6 months.
Treatment - Drugs
Intervention group: 30 mg pioglitazone daily for 6 months
Control group: OCP (LD) one pill daily for 6 months
Sponsors
Tehran University Of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Approved case of endometriosis with laparoscopy, patients in stage less than 4 according to rAFS criteria Exclusion criteria: Pregnant and breastfeeding women, Intake of OCP in recent month, Diabetes, Cardiac Functional Class III and IV, Liver dysfunction, Cancer diseases, Pelvic pain with other causes, Abnormal WBC count, FBS/Insulin less than 4.5 , Patients older than 35 years old who smoke more than 15 cigarette per day, Co-existence of multiple cardiovascular risk factors including: (old age, cigarette smoker, diabetes, blood pressure more than 160/100 and vascular disease), Thromboembolic disease, Recent major surgery with prolonged immobilization, Past history or presence of ischemic heart or stroke, Cardiac valvular disease, Migrain with aura or without aura in patients above 35 years old, No severe adhesions, No other treatment interfering with endometriotic lesions, No GnRh or corticosteroid therapy in recent 3 months, No surgical intervention other than endometrioma evacuation in recent 12 months
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endometriosis stage. Timepoint: At the beginning/after 6 months. Method of measurement: by ob-gyn specialist with rAFS criteria.;Endometriosis score. Timepoint: At the beginning/after 6 months. Method of measurement: by ob-gyn specialist with rAFS criteria. | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective endometriosis symptoms. Timepoint: At the beginning/after 3 months and 6 months. Method of measurement: modified Biberoglu and Behrman symptom severity scale (BB).;Patients’ perception of sensory and affective dimension of pain. Timepoint: At the beginning/after 3 months and 6 months. Method of measurement: Short-Form McGill Pain Questionnaire.;Severity of pain. Timepoint: At the beginning/after 3 months and 6 months. Method of measurement: scale of 0 to 5.;Quality of life. Timepoint: At the beginning/after 3 months and 6 months. Method of measurement: SF12.;Anxiety/Depression. Timepoint: At the beginning/after 3 months and 6 months. Method of measurement: HADS questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHaydeh Samiee
Tehran University of Medical Sciences
Outcome results
None listed