propofol injection pain. Drugs, medicaments and biological substances causing adverse effects in therapeutic use
Conditions
Interventions
Intervention 1: efedrine- 0.1mg/kg- 2cc- iv-before propofol injection. Intervention 2: lidocaine 2%- 2cc- iv- before propofol injection. Intervention 3: ketamine- 0.1mg/kg- 2cc- iv- before propofol in
Prevention
Placebo
efedrine- 0.1mg/kg- 2cc- iv-before propofol injection
lidocaine 2%- 2cc- iv- before propofol injection
ketamine- 0.1mg/kg- 2cc- iv- before propofol injection
normal saline- placebo- 2cc- iv- before propofol injection
Sponsors
Vice chancellor for research, .... University of shahid sadoughi medical university
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: ; All of patients in ASA class I, who are candidated for elective surgery and anesthesia with propofol and this anesthesia is the first experience for them; exclusion criteria: ;Any patients that has unpredictable complications during information recording to (such asbronchospasms , ....) pain at the Injection site before or during the study drugs injection (before injection of propofol) Previous sensitivity to study drugs anxiety and lack of cooperation;
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: before starting. after injection and before tracheal int. after tracheal int. Method of measurement: mmHg by noninvasive automatic device.;Propofol injection pain. Timepoint: during injection. Method of measurement: 4 point visual. | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate. Timepoint: before starting. after injection and before tracheal int. after tracheal int. Method of measurement: bit/min by EKG and pulsoximetry. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed