Comparison of cinnarizine and sodium valporate in migraine prophylaxis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201102055729N2

Enrollment

Registered

2011-03-04

Start date

2010-10-03

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Common migraine. Condition 2: Classical migraine. Migraine without aura [common migraine] Migraine with aura [classical migraine]

Interventions

Intervention 1: Cinnarizne tablet 25 mg twice a day orally, for 12 weeks. Intervention 2: Sodium valporate tablets 200mg twice a day orally, for 12 weeks.

Treatment - Drugs

Cinnarizne tablet 25 mg twice a day orally, for 12 weeks

Sodium valporate tablets 200mg twice a day orally, for 12 weeks

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: more than 4 and less than 10 attacks monthly, age at the onset of headache less than 50 years, age 18-65 years, discontinuation of other prophylactic drugs one month prior to the study, interval between attacks more than 48 hours Exclusion criteria: pregnancy and breast feeding, non-migraine headaches, overuse of medications in migraine attacks (consumption of NSAID, Ergots & Triptans more than 8 days a month), substance and alcohol abuse, illiteracy of patients and their family (unable to fill diaries)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Severity of headache. Timepoint: in each migraine attack. Method of measurement: patient will record the headache severity in daily notes as VAS (from 1 to 10) & physician registers them every 4 weeks.;Duration of migraine attack. Timepoint: in each migraine attack. Method of measurement: patient records the hours of headache in each attack , physician register them every 4 weeks.;Headache frequency. Timepoint: every 4 week. Method of measurement: According to patients daily notes.;Analgesic use. Timepoint: every 4 week. Method of measurement: According to patients daily notes.	—

Measure

Time frame

Severity of headache. Timepoint: in each migraine attack. Method of measurement: patient will record the headache severity in daily notes as VAS (from 1 to 10) & physician registers them every 4 weeks.;Duration of migraine attack. Timepoint: in each migraine attack. Method of measurement: patient records the hours of headache in each attack , physician register them every 4 weeks.;Headache frequency. Timepoint: every 4 week. Method of measurement: According to patients daily notes.;Analgesic use. Timepoint: every 4 week. Method of measurement: According to patients daily notes.

—

Secondary

Measure	Time frame
Clinical side effects. Timepoint: every 4 weeks. Method of measurement: According to patients daily notes.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Arash Bostani

Emam Reza Hospitl of Kermanshah

arashbostani2000@yahoo.com+98 83 1427 6309

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026