coronay artery disease. Atherosclerotic heart disease
Conditions
Interventions
Intervention 1: N acetyl cyctein 600 mg orally last night of operation. Intervention 2: propofol infusion during anesthesia and operation( 50-100 mic/kg/min).
Treatment - Drugs
N acetyl cyctein 600 mg orally last night of operation
propofol infusion during anesthesia and operation( 50-100 mic/kg/min)
Sponsors
Bushehr University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: The study population of patients are 45 -75 years old candidates for coronary artery bypass surgery. Exclusion criteria consist of : Emergency coronary bypass surgery; Chronic renal failure; Chronic corticosteroid therapy; Re exploration surgery; Chronic inflammatory disease and autoimmune disease; Severe left ventricular failure(EF less than 35%); Liver disease; Infectious disease after surgery
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CRP. Timepoint: Last night before surgery- 4 and 24 hours after surgery. Method of measurement: arterial blood.;Cytokines. Timepoint: after induction- 15 min, 3 and 24 hour after bypass surgery-. Method of measurement: arterial line. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sysyolic blood pressure. Timepoint: pre induction of anesthesia- 15,30, 60 minute after bypass- in icu admit. Method of measurement: Arterial line.;Diastolic blood pressure. Timepoint: preinduction- 15,30,60 minute post anesthesia- icu admit. Method of measurement: arterial line.;Mean arterial pressure. Timepoint: preinduction- 15,30,60 minutes after bypass-icu admit. Method of measurement: arterial line.;Heart rate. Timepoint: preinduction of anesthesia- 15,30,60 minutes after bypass- icu admit. Method of measurement: arterial line. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAbdolrasoul Anvaripour
Bushehr University of Medical Sciences
Outcome results
None listed