Brucellosis. Brucellosis
Conditions
Interventions
Intervention 1: doxycycline 200 mg/daily for six weeks plus streptomycin 1000mg/daily for the first three weeks. Intervention 2: ofloxacin 800 mg/daily plus rifampin 15 mg/kg daily for six weeks. Inte
Treatment - Drugs
doxycycline 200 mg/daily for six weeks plus streptomycin 1000mg/daily for the first three weeks
ofloxacin 800 mg/daily plus rifampin 15 mg/kg daily for six weeks
doxycycline 200 mg/daily plus rifampin 15 mg/kg daily for six weeks
Sponsors
Vice-Chancellor of Research and Technology,Hamedan University of Medical sciences
Eligibility
Sex/Gender
All
Age
17 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: clinical presentations compatible with brucellosis in the presence of significant titers of specific antibodies (standard tube agglutination = 1/160, coomb’s test = 1/160, 2-mercaptoetanol = 1-80, or Brucella IgG-ELISA > 12) and/or a positive blood culture for Brucella Exclusion criteria: age under 17 years, brucella endocarditis, neurobrucellosis, pregnancy, renal failure, hepatic failure, a history of treatment for brucellosis in the last six months
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Therapeutic failure. Timepoint: 6 weeks. Method of measurement: Physical examination.;Relapse. Timepoint: 6 months. Method of measurement: physical examination and 2-ME testing (2-ME>or=1/80). | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction. Timepoint: 2, 4, 6 weeks. Method of measurement: observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyyed Hamid Hashemi
Hamedan University of Medical sciences
Outcome results
None listed