Diabetes. Non-insulin-dependent diabetes mellitus
Conditions
Interventions
Intervention 1: 100mg/kg Placebo in a glass of water every 8 hours in addition to the oral synthetic antidiabetic drugs for 3 months. Intervention 2: Nettle extract at the dose of 100 mg per Kilogram
Placebo
Treatment - Drugs
100mg/kg Placebo in a glass of water every 8 hours in addition to the oral synthetic antidiabetic drugs for 3 months
Nettle extract at the dose of 100 mg per Kilogram of body weight every 8 hours in addition to the oral synthetic antidiabetic drugs for 3 months
Sponsors
Vice chancellor for research, Tabriz University of Medical Sciences
Nutritional Research center, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Fasting blood sugar more than 126 mg/dl and less than 300 mg/dl; Taking usual diabetes medicines like Glibenclamide and Metformin; Age 30-50 years in both sex; BMI less than 35 Kg/m2 Exclusion criteria: Illness background(cardiovascular, kidney, GI, inflectional, liver, Thyroids, allergies, etc); Use NSAIDs, Aspirin, Warfarin, and diuretic drugs; Smoking and use of alcohol, Herbal supplements, diet supplements, Vitamin supplements, Insulin, Anti blood pressure drugs and lipid reducer drugs; Pregnancy and Lactating; Serum Triglyceride more than 400 mg/dl; Do not use of nettle extract more than 3 days.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycosylated hemoglobin (HbA1c). Timepoint: 2 months. Method of measurement: Radioimmunoassay method.;Fasting Blood Sugar. Timepoint: 2 months. Method of measurement: Glucose oxidase method.;Total Cholesterol. Timepoint: 2 months. Method of measurement: Enzymatic.;Triglyceride. Timepoint: 2 months. Method of measurement: Enzymatic.;HDL-cholesterol. Timepoint: 2 months. Method of measurement: Enzymatic.;LDL-cholesterol. Timepoint: 2 months. Method of measurement: Friedewald equation.;Insulin. Timepoint: 2 months. Method of measurement: ELISA method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin resistance. Timepoint: 2 months. Method of measurement: Matius Equation.;Malondyaldehide. Timepoint: 2 months. Method of measurement: Fluorimetry.;Super Oxidase Dismutase. Timepoint: 2 months. Method of measurement: Spectrophotometric.;Glutathione Peroxidase. Timepoint: 2 months. Method of measurement: Spectrophotometric.;Total Antioxidant Capacity. Timepoint: 2 months. Method of measurement: Fluorescence Recovery After Photo bleaching. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed