The Effect of curcumin on patients with systemic inflammatory response syndrome

The Effect of curcumin on oxidative indices, inflammatory factors and Sequential Organ Failure Assessment Score in patients with systemic inflammatory response syndrome

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110123005670N7

Enrollment

Registered

2017-12-15

Start date

2017-12-22

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis/At risk of sepsis. Systemic inflammatory response syndrome (SIRS) of non-infectious origin

Interventions

Intervention 1: Intervention group: Two curcumin capsules(Sina Pharmaceutical Company) of 80 mg per day for ten days. Intervention 2: Control group: Common formulas.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Critically ill ICU patients with APACHE II score of 15-30; Positive SIRS; Aged over 18 and under the age of 60 years; Hospitalization at least 10 days in ICU; Recipients of enteral nutrition formula

Exclusion criteria

Exclusion criteria: Parenteral feeding; Intolerance to enteral feeding and gavage solution; Patient is waiting for death in the 24 future hourse; HIV positive patient; pregnant and lactating women; Ileus; Mellitus diabetes; Short bowel syndrome; Pancreatitis; Immune disorders

Design outcomes

Primary

Measure	Time frame
Inflammation. Timepoint: First, fifth, and tenth day. Method of measurement: Interleukin 6 and tumor necrosis factor-alpha, Forkhead box P3, NLR family pyrin domain containing 3, interferon-gamma, and nuclear factor kappa B, high mobility group box 1, Interleukin 8 ,Interleukin 17 and Interleukin 22, Interleukin 10, presepsin, TLR4, ICAM- 1, VCAM-1and PCT.;Oxidative stress. Timepoint: First, fifth, and tenth day. Method of measurement: Total antioxidant capacity and malondialdehyde, Nrf2,SOD, GPX, BAX, BCL2.;Sequential Organ Failure Assessment (SOFA). Timepoint: First, fifth, and tenth day. Method of measurement: Questionnaire.	—

Measure

Time frame

Inflammation. Timepoint: First, fifth, and tenth day. Method of measurement: Interleukin 6 and tumor necrosis factor-alpha, Forkhead box P3, NLR family pyrin domain containing 3, interferon-gamma, and nuclear factor kappa B, high mobility group box 1, Interleukin 8 ,Interleukin 17 and Interleukin 22, Interleukin 10, presepsin, TLR4, ICAM- 1, VCAM-1and PCT.;Oxidative stress. Timepoint: First, fifth, and tenth day. Method of measurement: Total antioxidant capacity and malondialdehyde, Nrf2,SOD, GPX, BAX, BCL2.;Sequential Organ Failure Assessment (SOFA). Timepoint: First, fifth, and tenth day. Method of measurement: Questionnaire.

—

Secondary

Measure	Time frame
Nutrition status. Timepoint: ???1? 5? ??? 10. Method of measurement: Received calorie measuring.;Biochemical factors. Timepoint: ???1? 5? ??? 10. Method of measurement: Biochemistry kit.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Ali Tarighat-Esfanjani

Tabriz University of Medical Sciences

tarighata@tbzmed.ac.ir+98 41 3335 2292

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026