Traumatic brain injury. Superficial injury of head
Conditions
Interventions
Intervention 1: Intervention group: Capsules containing 25 mg of calebin-A and 3 mg of piperine, manufactured by Sami-sabinsa Co Ltd from India, will be administered once daily for 7 days through an N
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients 18 years and older who are admitted to ICUs due to traumatic brain injury. Having a score of 7 or higher on the Glasgow Coma Scale Patients connection to the ventilator
Exclusion criteria
Exclusion criteria: Inability to initiate nutritional support within the first 24 to 48 hours of hospitalization Receiving positive inotropic drugs, including Dopamine, Dobutamine, and Epinephrine Pregnancy and breastfeeding Having a known food allergy History of malignancy (cancer) and autoimmune disorder History of liver failure Severe obesity BMI over 40 Human immunodeficiency virus (HIV) infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory condition(CRP, ESR, IL-6 ,TNF-a). Timepoint: Before the start of the intervention and 7 days after it. Method of measurement: Blood test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical outcomes (SOFA and NUTRIC score). Timepoint: Before starting the intervention (day 1) and 7 days later (day8). Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Ali tarighat esfanjani
Tabriz University of Medical Sciences
Outcome results
None listed