Coronary artery disease. Atherosclerotic heart disease of native coronary artery with angina pectoris
Conditions
Interventions
Intervention 1: Intervention group1: The first intervention group will receive sodium selenite-enriched yeast capsule at a dose of 200 µg for 8 weeks. Yeast supplement enriched with sodium selenite ha
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: Willingness to participate in the study and sign informed consent form after full knowledge of the purpose and method of the study Men and women with 30-65 years age range Diagnosis of atherosclerosis by a physician based on angiography results with at least 50% vascular obstruction in at least one vessel Not using any antioxidant and anti-inflammatory supplements for at least 1 month before starting the study Patients with overweight and obesity (BMI = 25 - 35 Kg / m²)
Exclusion criteria
Exclusion criteria: A variety of malignancies, autoimmune and infectious diseases Chronic diseases such as liver, kidney and thyroid diseases Pregnancy and lactation Exposure to any side effects during the study Consumers of antacids, antibiotics, alcohol and cigarette users Blood disease and osteoporosis allergies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glutathione peroxidase level. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: Biochemical.;Nitric oxide. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: biochemical.;Malondialdehyde level. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: biochemical.;Triglyceride. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: biochemical.;HDL- cholestrol. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: biochemical.;LDL-cholestrol. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: biochemical.;Total cholestrol. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: biochemical.;Fasting blood glucose. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: biochemical.;Fasting insulin. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: biochemical.;Hemoglobin A1c. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: biochemical.;Superoxide dismotase. Timepoint: before intervention and 8 weeks after intervention. Method of measurement: biochemical. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Tarighat Esfanjani
Tabriz University of Medical Sciences
Outcome results
None listed