Effect of curcumin on systemic inflammatory response syndrome

Effect of curcumin on coagulation factors, anti-inflammatory factor and Simplified Acute Physiology Score ? in patients with systemic inflammatory response syndrome

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110123005670N27

Enrollment

Registered

2019-02-24

Start date

2018-12-26

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis/at risk of sepsis. Systemic inflammatory response syndrome (SIRS) of non-infectious origin

Interventions

Intervention 1: Intervention group: Two 80-mg capsules of nano-curcumin (Sina Pharmaceutical Company) per day for 10 days. Intervention 2: Control group: entera meal formula (karen company) or blender

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Critically ill patients with APACHE II score of 15-30 Positive SIRS Age over 18 and under 60 At least 10 days hospitalization in ICU Patients who received enteral nutrition formula

Exclusion criteria

Exclusion criteria: Parenteral feeding Enteral nutrition and gavage formula intolerance Patients expected to die within the next 24 hours HIV positive patients Pregnant and lactating women ileus Immune disorder Diabetes melitus Short bowel syndrome Pancreatitis

Design outcomes

Primary

Measure	Time frame
Protein C. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: ELISA Kit.;Partial Thromboplastin time. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: ELISA kit.;Prediction of death. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: Simplified Acute Physiology Score questionnaire.;Transforming growth factor ß1. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: ELISA kit.	—

Measure

Time frame

Protein C. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: ELISA Kit.;Partial Thromboplastin time. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: ELISA kit.;Prediction of death. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: Simplified Acute Physiology Score questionnaire.;Transforming growth factor ß1. Timepoint: Day 1, 5 and 10 of intervention. Method of measurement: ELISA kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ali Tarighat Esfanjani

Tabriz University of Medical Sciences

tarighata@tbzmed.ac.ir+98 41 1335 7581

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026