effect of oral clonidine on surgical blood loss

Comparison of Effect of Oral Clonidine Premedication on Blood Loss in Lumbar Spinal Posterior Fusion Surgery with that of Plasebo

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201101205652N1

Enrollment

Registered

2011-03-01

Start date

2009-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

blood loss during posterior spinal fusion surgery. Fracture of lumbar vertebra

Interventions

Intervention 1: clonidine tablet (oral), 200 microgram, to the study group ,60 - 90 minutes before anesthesia. Intervention 2: placebo (pantoprazole tablet), to control group, 60 - 90 minutes before a

Treatment - Drugs

Placebo

clonidine tablet (oral), 200 microgram, to the study group ,60 - 90 minutes before anesthesia

placebo (pantoprazole tablet), to control group, 60 - 90 minutes before anesthesia

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: 20-65yr old with American Society of Anesthesia (ASA) physical status of I-II candidated for posterior fusion of lumbar spine at 3 to 4 levels due to traumatic vertebral fracture The exclusion criteria: significant underlying disease (hypertension, hepatic or renal disease, coagulation defects, diabetes mellitus), being under beta-blocker, calcium channel blocker, dioxin, tricyclic antidepressant, anticoagulant or clonidine treatment, drug or alcohol abuse.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Surgical blood loss. Timepoint: end of operation. Method of measurement: milliliter.	—

Secondary

Measure	Time frame
Surgeon's satisfaction of a bloodless field. Timepoint: end of surgery. Method of measurement: surgeon's satisfaction scoring system.;Dose of remifentanil administered per hour to keep mean arterial pressure between 60 - 70 mmHg. Timepoint: end of operation/anesthesia. Method of measurement: milligram/hour.;Need for nitroglycerin added to remifentanil to keep mean arterial pressure between 60 - 70 mmHg. Timepoint: end of surgery. Method of measurement: number of petients who needed TNG in each group.;Occurance of severe/refractive bradycardia (as a complication of clonidine). Timepoint: when occured during operation/anesthesia. Method of measurement: number of patients.	—

Measure

Time frame

Surgeon's satisfaction of a bloodless field. Timepoint: end of surgery. Method of measurement: surgeon's satisfaction scoring system.;Dose of remifentanil administered per hour to keep mean arterial pressure between 60 - 70 mmHg. Timepoint: end of operation/anesthesia. Method of measurement: milligram/hour.;Need for nitroglycerin added to remifentanil to keep mean arterial pressure between 60 - 70 mmHg. Timepoint: end of surgery. Method of measurement: number of petients who needed TNG in each group.;Occurance of severe/refractive bradycardia (as a complication of clonidine). Timepoint: when occured during operation/anesthesia. Method of measurement: number of patients.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Taghipour Anvari

Tehran ( Iran) University of Medical Sciences

ztaghipour@tums.ac.ir+98 21 6650 9059

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026