propofol, etomidate or propofol with etomidate which one influences quality of laryngeal mask replacement and hemodynamic stability lesser.

Comparing the effect of three methods for induction of anesthesia (propofol, Etomidate, propofol+Etomidate) on quality of laryngeal mask airway replacement and hemodynamic stability in elective surgeries

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201101054731N5

Enrollment

Registered

2012-01-15

Start date

2011-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: 1:Heart rate changes due to induction of anesthesia. Condition 2: Blood pressure changes due to induction of aneasthesia. Bradycardia,unspecified Nonspecific low blood-pressure reading

Interventions

Intervention 1: Propofol 2.5mg/kg will be given once to put the patient to sleep for surgery. Intervention 2: Etomidate 0.3mg/kg will be given once to put the patient to sleep for surgery. Interventio

Prevention

Propofol 2.5mg/kg will be given once to put the patient to sleep for surgery

Etomidate 0.3mg/kg will be given once to put the patient to sleep for surgery

Propofol 1mg/kg plus Etomidate 0.2 mg/kg will be given once to put the patient to sleep for surgery

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Adult patients with ASA (American society of Anesthesiologist) class I and II; age between 18-70 years; undergoing surgery with LMA (Laryngeal Mask Airway). Exclusion criteria: Pharynx or larynx pathology; mouth opening less than 2cm; bronchial asthma; cardiovascular diseases or mallampati 3-4.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA, after insertion LMA and every 1min up to 3min. Method of measurement: non invesive monitoring devices with automatic cuff.;Dyastolic blood pressure. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA, after insertion LMA and every 1min up to 3min. Method of measurement: non invesive monitoring devices with automatic cuff.;Mean arterial pressure. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA, after insertion LMA and every 1min up to 3min. Method of measurement: non invesive monitoring devices with automatic cuff.;Heart rate. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA ,after insertion LMA and every 1min up to 3min. Method of measurement: continuos ECG monitoring.;Oxygen saturation. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA ,after insertion LMA and every 1min up to 3min. Method of measurement: Pulse oxymetry devices.;The apnea time after induction anesthesia until return of the first spotaneos ventilation. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA ,after insertion LMA and every 1min up to 3min. Method of measurement: continuos ECG monitoring.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA, after insertion LMA and every 1min up to 3min. Method of measurement: non invesive monitoring devices with automatic cuff.;Dyastolic blood pressure. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA, after insertion LMA and every 1min up to 3min. Method of measurement: non invesive monitoring devices with automatic cuff.;Mean arterial pressure. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA, after insertion LMA and every 1min up to 3min. Method of measurement: non invesive monitoring devices with automatic cuff.;Heart rate. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA ,after insertion LMA and every 1min up to 3min. Method of measurement: continuos ECG monitoring.;Oxygen saturation. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA ,after insertion LMA and every 1min up to 3min. Method of measurement: Pulse oxymetry devices.;The apnea time after induction anesthesia until return of the first spotaneos ventilation. Timepoint: Before anesthesia,after induction of anesthesia,before insertion of LMA ,after insertion LMA and every 1min up to 3min. Method of measurement: continuos ECG monitoring.

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Secondary

Measure	Time frame
Quality of laryngeal mask airway replacement. Timepoint: After replacement larygeal mask airway. Method of measurement: Insertion condition were graded in a system modifid from lund and stovener.;Number of attempts for LMA insetion. Timepoint: Number of attempt. Method of measurement: observation.;Quality of airway. Timepoint: After replacement larygeal mask airway. Method of measurement: observation.	—

Measure

Time frame

Quality of laryngeal mask airway replacement. Timepoint: After replacement larygeal mask airway. Method of measurement: Insertion condition were graded in a system modifid from lund and stovener.;Number of attempts for LMA insetion. Timepoint: Number of attempt. Method of measurement: observation.;Quality of airway. Timepoint: After replacement larygeal mask airway. Method of measurement: observation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamzeh Hosseinzadah

Tabriz University of Medical Sciences

hosseinz@tbzmed.ac.ir+98 41 1334 7055

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026