Bipolar disorder,Manic episode. Manic episode
Conditions
Interventions
Intervention 1: During treatment with ECT that often lasts between 6 to 10 sessions, sodium valproate is continued in the control group. Intervention 2: During treatment with ECT that often lasts bet
Treatment - Drugs
During treatment with ECT that often lasts between 6 to 10 sessions, sodium valproate is continued in the control group.
During treatment with ECT that often lasts between 6 to 10 sessions, sodium valproate is discontinued in the case group.
Sponsors
Hamedan univercity of medical science
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Manic episode based on DSM IV-TR 2. Age between 18 and 60 years 3. Elementary school education (at least) 4. ECT administer by attending physician Exclusion criteria: 1.Concurrent anticonvulsant therapy (except sodium valproate) 2. Severe cognitive impairment (MMSE = 19) befor the first session of ECT 3.Uncontrolled physical condition 4.Pregnant and nursing women 5. History of epilepsy 6. LFT > 3 fold the normal range
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seizure threshold. Timepoint: all session of ECT. Method of measurement: observation.;Duration of seizure. Timepoint: all session of ECT. Method of measurement: EEG.;Cognetive side effect. Timepoint: Befor the 1st ECTsession and after 3rd and 6th session. Method of measurement: MMSE. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Gholamreza Bigdeloo
Hamedan univercity of medical sciences
Outcome results
None listed