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Comparison of effect of methyl phenidate (Ritalin) and bupropion in children with hyperactivity disorder

Double-blind randomized comparison of efficacy and side effects of Bupropion versus methyl phenidate in children with Attention Deficit Hyperactivity Disorder (ADHD)

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201012295500N1
Enrollment
40
Registered
2012-03-29
Start date
2010-09-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

attention deficit hyperactivity disorder. Disturbance of activity and attention

Interventions

Intervention 1: Bupropion, 75 milligram tablets, orally, two times a day, Morning and afternoon. Intervention 2: Methylphenidate (Ritalin) tablets, 10 mg, orally, two times a day, morning and evening,
Treatment - Drugs
Bupropion, 75 milligram tablets, orally, two times a day, Morning and afternoon
Methylphenidate (Ritalin) tablets, 10 mg, orally, two times a day, morning and evening, based on weight 0.3-0.8 mg/kg

Sponsors

Research vice chancellor of Mashad university of medical sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 12 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1-Children 6 to 12 years old with diagnosis of ADHD on the basis of DSM-IV-TR; 2-children without MR (IQ>70); 3-children without medical and neurologic problems specially with a history of epilepsy; 4-children without eating disorders (because of being prone to seizure due to bupropion); 5-agreement of parents in research participation; 6-the child that does not have the history of using Methyl phenidate and Bupropion and other psychiatric drugs. Exclusion criteria: 1-disagreement of parents during the research; 2-existance of severe side effects like neurologic disorders such as convulsion in curing groups.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Assessment of children (C-GAS). Timepoint: Before intervention, the fourth week and eighth week after the start of intervention. Method of measurement: Teacher and parent questionnaire.;Attention Deficit, hyperactivity Disorder Scale. Timepoint: Before intervention, the fourth week and eighth week after the start of intervention. Method of measurement: Teacher and parent questionnaire.

Secondary

MeasureTime frame
Side effects of bupropion. Timepoint: the fourth week and eighth week after the start of intervention. Method of measurement: Questionnaire check list.;Side effects of stimulant drugs. Timepoint: the fourth week and eighth week after the start of intervention. Method of measurement: Questionnaire check list.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Pasandideh

Mashad university of medical sciences

pasandidem821@mums.ac.ir+98 51171127019

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026