PCOS. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Metformin, 1500 mg daily, orally for 3 months. Intervention 2: Simvastatin, 20 mg daily, orally for 3 months.
Treatment - Drugs
Metformin, 1500 mg daily, orally for 3 months
Simvastatin, 20 mg daily, orally for 3 months
Sponsors
Alzahra Hospital Research Center
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age 20 to 40 years, having PCOS means: A - clinical symptoms and / or biochemical parameters of hyperandrogenism + irregular mens, having normal levels of bilirubin, creatinine , BUN, SGOT , SGPT , TSH Exclusion criteria: Presence of congenital adrenal hyperplasia, hyperprolactinemia, Cushing's syndrome, androgen secreted by tumors, thyroid disease, diabetes mellitus, hypertension, history of cardiovascular disease, Using OCP and other steroid hormones or any drugs affecting ovarian function, insulin sensitivity or lipid profiles, Pregnancy, incidence of any adverse effects (liver and renal function tests elevation) during treatment
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BP. Timepoint: Before clinical trial and three months after. Method of measurement: MmHg by using a mercury manometer.;Weight. Timepoint: Before clinical trial and three months after. Method of measurement: By Digital Scale.;BMI. Timepoint: Before clinical trial and three months after. Method of measurement: Weight to kilograms / the square of height in meters.;Hirsutism. Timepoint: Before clinical trial and three months after. Method of measurement: Hirsutism score.;Acne. Timepoint: Before clinical trial and three months after. Method of measurement: Clinical Finding.;Irregular Mens. Timepoint: Before clinical trial and three months after. Method of measurement: Clinical Finding.;Prolactin. Timepoint: Before clinical trial and 3 months after. Method of measurement: Laboratory results.;GTT. Timepoint: Before clinical trial and three months after. Method of measurement: Laboratory results.;FSH. Timepoint: Before clinical trial and three months after. Method of measurement: Laboratory results.;LH. Timepoint: Before clinical trial and three months after. Method of measurement: Laboratory results.;Total testosterone. Timepoint: Before clinical trial and three months after. Method of measurement: Laboratory results.;Free testosterone. Timepoint: Before clinical trial and three months after. Method of measurement: Laboratory results.;SHBG. Timepoint: Before clinical trial and three months after. Method of measurement: Laboratory results.;DHEAS. Timepoint: Before clinical trial and 3 months after. Method of measurement: Laboratory results.;Serum Insulin. Timepoint: Before clinical trial and three months after. Method of measurement: Laboratory results.;Insulin sensitivity Index. Timepoint: Before clinical trial and three months after. Method of measurement: Laboratory results.;Triglycerides. Timepoint: Before clinical trial and three months after. Method of measurement: Laboratory results.;Total cholesterol. Timepoint: Before clinical trial and three months after. Method o | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Kazemivand
Tabriz University of Medical Sciences
Outcome results
None listed