Determining the effect of myo-inositol on the outcomes of ovulation induction cycles.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20101227005485N13

Enrollment

Registered

2025-04-16

Start date

2025-04-21

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility

Interventions

Intervention 1: Intervention group: The intervention group will receive 2000 micrograms of myoinositol (Inofolic sachet, Lo. Li Pharma. Tehran, Iran) along with 200 micrograms of folic acid (Raha phar

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age between 20 and 40 Candidate for direct sperm injection into each mature egg (ICSI) / In Vitro Fertilization (IVF) treatment Trilinear endometrium above 8mm before embryo transfer Anti-Müllerian hormone > 1

Exclusion criteria

Exclusion criteria: Having any underlying medical conditions (metabolic or endocrine disorders). Structural abnormalities of the uterus

Design outcomes

Primary

Measure	Time frame
Biochemical pregnancy. Timepoint: Two weeks after embryo transfer. Method of measurement: Serum level of hCG-ß.;Clinical pregnancy. Timepoint: 4 weeks after fetal transfer. Method of measurement: Vaginal ultrasound and see a pregnancy bag.;Live birth rate. Timepoint: After delivery. Method of measurement: Patient file.	—

Secondary

Measure	Time frame
The rate of spontaneous abortion. Timepoint: Before the 20th week of pregnancy. Method of measurement: Ultrasound.;Preterm births. Timepoint: before the 37th week of pregnancy. Method of measurement: Ultrasound.;Number of oocytes retrieved. Timepoint: The ovulation day. Method of measurement: Microscopic examination.;Quality of retrieved oocytes. Timepoint: The ovulation day. Method of measurement: Microscopic examination.;Number of oocytes in meiosis II. Timepoint: After egg retrieval. Method of measurement: Microscopic examination.;Fetal quality. Timepoint: Two days after embryo transfer. Method of measurement: Diagnosis of the embryo specialist according to embryological criteria.;Oocyte fertilization rate. Timepoint: First day after embryo transfer. Method of measurement: Diagnosis of the embryo specialist according to embryological criteria.	—

Measure

Time frame

The rate of spontaneous abortion. Timepoint: Before the 20th week of pregnancy. Method of measurement: Ultrasound.;Preterm births. Timepoint: before the 37th week of pregnancy. Method of measurement: Ultrasound.;Number of oocytes retrieved. Timepoint: The ovulation day. Method of measurement: Microscopic examination.;Quality of retrieved oocytes. Timepoint: The ovulation day. Method of measurement: Microscopic examination.;Number of oocytes in meiosis II. Timepoint: After egg retrieval. Method of measurement: Microscopic examination.;Fetal quality. Timepoint: Two days after embryo transfer. Method of measurement: Diagnosis of the embryo specialist according to embryological criteria.;Oocyte fertilization rate. Timepoint: First day after embryo transfer. Method of measurement: Diagnosis of the embryo specialist according to embryological criteria.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Nazli Navali

Tabriz University of Medical Sciences

navalin@tbzmed.ac.ir+98 41 3553 9161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026