Repeated implantation failure. Female infertility of uterine origin
Conditions
Interventions
Intervention group: Amlodipine 5 mg once every night with the first cycle monitoring will usually start on day 9-11 of the cycle. The treatment will continue until the pregnancy test is done. If the p
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Women aged 18 to 40 with ICSI <38 and ICSI candidate for frozen embryo transfer Typically, higher baseline blood pressure Equal to 60/100 mm Hg before embryo transfer. The serum FSH level is not higher than 14 mli/iu Patients who have a normal uterine cavity in hysterosalpingography Those who do not contraindicate the use of Amlodipine, such as heart and liver patients Patients who do not have a history of irregular heart rate or who do not consume blood pressure pills.
Exclusion criteria
Exclusion criteria: Patients who have been taking medication interfered with Amlodipine over a month The women who have a blood pressure of 60/100 (mmHg) or less just before the prescribing the medicine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean Pulsatility index of uterine artery. Timepoint: Before intervention and 2 weeks later. Method of measurement: Doppler sonography of uterine arteries.;Mean resistance index of uterine artery. Timepoint: Before intervention and 2 weeks later. Method of measurement: Doppler sonography of uterine arteries. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy rate. Timepoint: 12 days following embryo transfer. Method of measurement: Blood test, BHCG.;Implantation rate: Gestational sac. Timepoint: in 6 weeks after pregnancy. Method of measurement: vaginal sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Nazli Navali
Tabriz University of Medical Sciences
Outcome results
None listed