medical abortion. termination of pregnancy: · legal · therapeutic therapeutic abortion
Conditions
Interventions
Intervention 1: Misoprostol, 400 microgram, vaginal, every 4 hours, within 48 hours. Intervention 2: Misoprostol, 400 microgram, sublingual , every 4 hours, within 48 hours. Intervention 3: Misoprosto
Treatment - Drugs
Misoprostol, 400 microgram, vaginal, every 4 hours, within 48 hours
Misoprostol, 400 microgram, sublingual , every 4 hours, within 48 hours
Misoprostol, 400 microgram, vaginal, then 400 microgram sublingual every 4 hours, within 48 hours
Sponsors
Vice chancellor for research of school of medicine , Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: inclusion criteria: any pregnant women with gestational age of 13-24 weeks which has indication for medical pregnancy termination including fetal or maternal indication. exclusion criteria : any hypersensitivity to prostaglandins; pregnant women who are high risk for uterine rupture(having more than one history of histrotomy or section, having history of uterine classic or Tshape incision, having extensive surgery on the uterine fundos, multi-parity more than 5); pregnant women with IUD;pregnant women having medical conditions such as severe anemia, anticoagulation state, taking anticoagulative drugs, active liver disease, and cardiovascular disease; pregnant women having glaucoma; pregnant women having uncontrolled seizure; pregnant women having adrenal disease or taking corticosteroids such as in bronchial asthma
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abortion rate in 24 and 48 hour after starting misoprostol usage. Timepoint: after 24 and 48 hour. Method of measurement: physical exam and transvaginal sonography.;Side effect of misoprostol in each group. Timepoint: each hour. Method of measurement: observation and asking the patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| Residual of all or a part of placenta which need a surgical procedure. Timepoint: 24- 48 hour later. Method of measurement: vaginal sonography.;The duration from starting misoprostol to successful abortion. Timepoint: each hour. Method of measurement: observation, counting time. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Fatemeh Rahimi Sherbaf
Tehran University of Medical Sciences
Outcome results
None listed