Comparison of ketamine, ondansetron and mepredine in preventing post anesthesia shivering

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201012224923N1

Enrollment

120

Registered

2011-10-04

Start date

2010-03-13

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of shaking after general anesthesia. Other specified complications of surgical and medical care, not elsewhere classified

Interventions

Intervention 1: Amp Ketamine 20mg IV,10min before end of surgery. Intervention 2: Amp ondansetrone 4mg IV , 10min before end of surgery. Intervention 3: Amp Meperidine 20mg IV , 10min before end of

Prevention

Amp Ketamine 20mg IV,10min before end of surgery

Amp ondansetrone 4mg IV , 10min before end of surgery

Amp Meperidine 20mg IV , 10min before end of surgery

2cc Normal saline , 10min before end of surgery as a control group

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA Class I,II candidate for general anesthesia, age 18-50 Exclusion criteria: underling disease such as: epilepsy, allergy, CHF, Need for transfusion, duration of operation more than 1.5 h, laparascopic or endoscopic procedure

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Shivering. Timepoint: Before ETT, before IV administration , 5 min after administration and 1st, 5th , 10th, 15th ,30th of recovery period. Method of measurement: Visual analogue scale.	—

Secondary

Measure	Time frame
Blood Pressure. Timepoint: Before ETT, before IV administration , 5 min after administration and 1st, 5th , 10th, 15th ,30th of recovery period. Method of measurement: BP Cuff.;Heart Rate. Timepoint: Before ETT, before IV administration , 5 min after administration and 1st, 5th , 10th, 15th ,30th of recovery period. Method of measurement: Pulse oximeter , ECG.;Respiratory depression. Timepoint: Before ETT, before IV administration , 5 min after administration and 1st, 5th , 10th, 15th ,30th of recovery period. Method of measurement: Pulse oximeter.;Nausea & vomiting. Timepoint: Recovery and 1st, 5th , 10th, 15th ,30th min of recovery period. Method of measurement: Visual - questional.	—

Measure

Time frame

Blood Pressure. Timepoint: Before ETT, before IV administration , 5 min after administration and 1st, 5th , 10th, 15th ,30th of recovery period. Method of measurement: BP Cuff.;Heart Rate. Timepoint: Before ETT, before IV administration , 5 min after administration and 1st, 5th , 10th, 15th ,30th of recovery period. Method of measurement: Pulse oximeter , ECG.;Respiratory depression. Timepoint: Before ETT, before IV administration , 5 min after administration and 1st, 5th , 10th, 15th ,30th of recovery period. Method of measurement: Pulse oximeter.;Nausea & vomiting. Timepoint: Recovery and 1st, 5th , 10th, 15th ,30th min of recovery period. Method of measurement: Visual - questional.

—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026