Evaluation of a Correlation between the Time of Low Dose Fentanyl Injection and Hemodynamic Responses during Tracheal Intubation

Evaluation of a Correlation between the Time of Low Dose Fentanyl Injection and Hemodynamic Responses during Tracheal Intubation in Emam Khomeini Hospital

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT201012215363N2

Enrollment

120

Registered

2011-02-13

Start date

2006-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

circulatory change after intubation. Postprocedural disorder of circulatory system, unspecified

Interventions

Intervention 1: Group II: In this group patients received fentanyl (2 microg/kg) (Fentanyl – Janseen cilag - Belgium) 1min before tracheal intubation. Following induction with thiopental (5mg/kg) (Thi

Treatment - Drugs

Group II: In this group patients received fentanyl (2 microg/kg) (Fentanyl – Janseen cilag - Belgium) 1min before tracheal intubation. Following induction with thiopental (5mg/kg) (Thiopental – SANDOZ

Group I (control): Following induction with thiopental (5mg/kg) (Thiopental – SANDOZ - Austria) and atracorium (0.5mg/kg) (Atracurium 25– Aburahhan - Iran) an oral tracheal intubation was accomplished

Group III: In this group patients received fentanyl (2 microg/kg) (Fentanyl – Janseen cilag - Belgium) 3min before tracheal intubation. Following induction with thiopental (5mg/kg) (Thiopental – SANDO

Group IV: In this group patients received fentanyl (2 microg/kg) (Fentanyl – Janseen cilag - Belgium) 5min before tracheal intubation. Following induction with thiopental (5mg/kg) (Thiopental – SANDOZ

Group V: In this group patients received fentanyl (2 microg/kg) (Fentanyl – Janseen cilag - Belgium) 10min before tracheal intubation. Following induction with thiopental (5mg/kg) (Thiopental – SANDOZ

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA class I or II, Age between 20- 65 year, scheduled to undergo elective surgery under general anesthesia Exclusion criteria: any history of hypertension, intestinal obstruction, cachexia, dehydration; cardiac, coronary, neurological, respiratory or renal dysfunction; Patients with difficult intubation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: before induction, 1 minute after intubation. Method of measurement: ECG.;Systolic blood pressure. Timepoint: before induction, 1 minute after intubation. Method of measurement: NIBP.;Diastolic blood pressure. Timepoint: before induction, 1 minute after intubation. Method of measurement: NIBP.;Mean blood pressure. Timepoint: before induction, 1 minute after intubation. Method of measurement: NIBP.	—

Measure

Time frame

Heart rate. Timepoint: before induction, 1 minute after intubation. Method of measurement: ECG.;Systolic blood pressure. Timepoint: before induction, 1 minute after intubation. Method of measurement: NIBP.;Diastolic blood pressure. Timepoint: before induction, 1 minute after intubation. Method of measurement: NIBP.;Mean blood pressure. Timepoint: before induction, 1 minute after intubation. Method of measurement: NIBP.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Faramarz Dobakhti

Zanjan University of Medical Sciences

fdobakhti@zums.ac.ir+98 982414273636

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026