Comparison of the effects of intra venous and epidural fentanyl on pain relief? hemodynamic stability, airway resistance, pulmonary static compliance and arterial blood gas in patients with abdominal and thoracic trauma in ICU.

Comparison of the effects of intra venous and epidural fentanyl on pain relief, hemodynamic stability, airway resistance, pulmonary static compliance and arterial blood gas in patients with abdominal and thoracic trauma in ICU.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201012205426N1

Enrollment

Registered

2011-07-11

Start date

2010-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: chest trauma. Condition 2: Abdomen trauma. Multiple open wounds of thoracic wall ,Fracture of sternum,Multiple fractures of ribs ,Flail chest Open wound of abdominal wall ,Multiple open wounds of abdomen, lower back and pelvis,Other multiple injuries of abdomen, lower back and pelvis

Interventions

Intervention 1: Insertion of epidural catheter in the level of L1-T11 for administration of fentanyl (1 mic/kg/hour) for pain relief. Intervention 2: administration of fentanyl from intravenous line (

Treatment - Surgery

Treatment - Drugs

Insertion of epidural catheter in the level of L1-T11 for administration of fentanyl (1 mic/kg/hour) for pain relief

administration of fentanyl from intravenous line (2mic/kg/hour) for pain relif

Eligibility

Sex/Gender

All

Age

16 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with 16-80 year old age who are admitted in ICU due to chest or abdominal trauma and are under mechanical ventilation Exclusion criteria: Age under16 and above 80 yeasr old; BMI>30; Instability of spine; renal or hepatic insufficiency, ischemic heart disease,hypertension, diabetes mellitus; massive transfusion; shock and acute respiratory distress syndrome

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

Measure	Time frame
Decrease level of GCS. Timepoint: GCS is evaluated every 2 houre. Method of measurement: consciousness level with GCS-.;Respiratory depression. Timepoint: respratory rate is monitored continiously in ICU. Method of measurement: respiratory rate by icu monitoring devices.;Hypotension. Timepoint: BP is monitored every 1 hour-. Method of measurement: blood pressure with NIBP monitoring.;Heart rate. Timepoint: heart rate is monitored continiously in ICU. Method of measurement: Heart rate with ECG monitoring-.	—

Measure

Time frame

Decrease level of GCS. Timepoint: GCS is evaluated every 2 houre. Method of measurement: consciousness level with GCS-.;Respiratory depression. Timepoint: respratory rate is monitored continiously in ICU. Method of measurement: respiratory rate by icu monitoring devices.;Hypotension. Timepoint: BP is monitored every 1 hour-. Method of measurement: blood pressure with NIBP monitoring.;Heart rate. Timepoint: heart rate is monitored continiously in ICU. Method of measurement: Heart rate with ECG monitoring-.

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Primary

Measure	Time frame
Heart rate-. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: Heart rate with ECG monitoring-.;ABG. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: ABG analyzer.;Level of consciosness. Timepoint: t 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: by GCS score.;Static compliance-. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: static compliance from patient data of ventilator.;Airway resistance. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: airway resistance from patient data of ventilator.;Pain score-. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: pain score with visual analog score.;Blood pressure. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: By non invasive BP monitoring of ICU.	—

Measure

Time frame

Heart rate-. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: Heart rate with ECG monitoring-.;ABG. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: ABG analyzer.;Level of consciosness. Timepoint: t 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: by GCS score.;Static compliance-. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: static compliance from patient data of ventilator.;Airway resistance. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: airway resistance from patient data of ventilator.;Pain score-. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: pain score with visual analog score.;Blood pressure. Timepoint: at 0-2-6-24-50-54-72 hours after admission of patents in icu. Method of measurement: By non invasive BP monitoring of ICU.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Ahmadinejad

Kerman University of Medical Sciences

mehdia50@gmail.com+98 34 1223 5011

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026