Comparison of two fluid therapy methods with and without Lasix in crash injuries with lung contusion

Comparison of two fluid therapy methods with and without Lasix in crash injuries with lung contusion referred to Kerman Bahonar Hospital in 2023

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20101220005426N14

Enrollment

Registered

2023-03-24

Start date

2023-02-20

Completion date

Unknown

Last updated

2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Crush injuries. Condition 2: Lung contusion. Crush injuries of unspecified body region Contusion of lungs

Interventions

Intervention 1: Control group: Crystalloid infusion will be initiated for the patients as a one-liter bolus over 2 hours, followed by 6 liters per day until the patients be able to tolerate enteral fe

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: All adult patients (over 18 years old) with multiple trauma who were diagnosed with pulmonary contusion Having creatine kinase (CPK) values over 5000 U/L Non-invasive ventilation (NIV) due to hypoxia in the emergency department of Bahonar Hospital

Exclusion criteria

Exclusion criteria: Myocardial contusion Organ failure Chronic pulmonary disease Pulmonary embolism Need for massive transfusion Complications of of blood transfusion Spinal cord injury Acute kidney injury Not willing to participate in the study Death within the first 48 hours

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: At the beginning of the study and every hour after treatment up to 48 hours. Method of measurement: Sphygmomanometer.;Diastolic blood pressure. Timepoint: At the beginning of the study and every hour after treatment up to 48 hours. Method of measurement: Sphygmomanometer.;Mean arterial pressure. Timepoint: At the beginning of the study and every hour after treatment up to 48 hours. Method of measurement: It is calculated based on diastolic and systolic blood pressure.;Pulse rate. Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: Pulse oximeter.;Respiratory rate. Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: Counting over a minute.;Arterial partial Pressure of Oxygen (PaO2). Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: Blood gas analyzer.;Serum sodium. Timepoint: At the beginning of the study and every 6 hours after the initiation of treatment up to 48 hours. Method of measurement: AutoAnalyzer.;Oxygen saturation (SaO2). Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: Pulse oximeter.;Creatine kinase. Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: AutoAnalyzer.;Serum creatinine level. Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: AutoAnalyzer.;Intake/output. Timepoint: At the beginning of the study and every 6 hours after the initiation of treatment up to 48 hours. Method of measurement: Intake /output chart.;PaO2/FiO2 ratio. Timepoint: At the beginning of the study and every 6 hours after the initiation of treatment up to 48 hours. Method of measure	—

Measure

Time frame

Systolic blood pressure. Timepoint: At the beginning of the study and every hour after treatment up to 48 hours. Method of measurement: Sphygmomanometer.;Diastolic blood pressure. Timepoint: At the beginning of the study and every hour after treatment up to 48 hours. Method of measurement: Sphygmomanometer.;Mean arterial pressure. Timepoint: At the beginning of the study and every hour after treatment up to 48 hours. Method of measurement: It is calculated based on diastolic and systolic blood pressure.;Pulse rate. Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: Pulse oximeter.;Respiratory rate. Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: Counting over a minute.;Arterial partial Pressure of Oxygen (PaO2). Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: Blood gas analyzer.;Serum sodium. Timepoint: At the beginning of the study and every 6 hours after the initiation of treatment up to 48 hours. Method of measurement: AutoAnalyzer.;Oxygen saturation (SaO2). Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: Pulse oximeter.;Creatine kinase. Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: AutoAnalyzer.;Serum creatinine level. Timepoint: At the beginning of the study and every hour after the initiation of treatment up to 48 hours. Method of measurement: AutoAnalyzer.;Intake/output. Timepoint: At the beginning of the study and every 6 hours after the initiation of treatment up to 48 hours. Method of measurement: Intake /output chart.;PaO2/FiO2 ratio. Timepoint: At the beginning of the study and every 6 hours after the initiation of treatment up to 48 hours. Method of measure

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmadinejad Mehdi

Kerman University of Medical Sciences

m.ahmadinejad@kmu.ac.ir+98 34 0223 5011

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026