Comparison of the effect of norepinephrine with and without dobutamine on mortality and morbidity of children with septic shock

Comparison of the effect of norepinephrine with and without dobutamine on mortality and morbidity of children with septic shock admitted to the intensive care unit

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20101220005426N13

Enrollment

Registered

2023-01-26

Start date

2023-01-23

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic shock. Postprocedural septic shock

Interventions

Intervention 1: Control group: The first group receives epinephrine at a dose of 0.1 to 1 mcg/kg in addition to common supportive treatments. Intervention 2: Intervention group: The second group, in a

Eligibility

Sex/Gender

All

Age

2 Years to 14 Years

Inclusion criteria

Inclusion criteria: Children in the age group of 2 to 14 years Children with septic shock They need to transfer to the intensive care unit

Exclusion criteria

Exclusion criteria: Children with organ failure The patient's lack of consent, or if the patient is unable to answer, the patient's guardian's lack of consent The presence of heart failure, kidney and diabetes

Design outcomes

Primary

Measure	Time frame
Hemodynamic and blood supply findings (CO-MAP-HR). Timepoint: Measuring CO-MAP-HR at the beginning of the study (before the intervention) and then every hour until the end of the study. Method of measurement: Ecocardiography.;Vasopressor dependence days. Timepoint: The number of days that patients receive vasopressor. Method of measurement: Check list.;Urinary tract. Timepoint: At the beginning of the study and then every 6 hours until the end of the study. Method of measurement: Check list.;Duration of hospitalization in the intensive care unit. Timepoint: At the beginning of the study and then daily until the end of hospitalization in the relevant department. Method of measurement: Check list.;Serum lactate level. Timepoint: At the beginning of the study, then daily until the end of the study. Method of measurement: AutoAnalyzer.;Electrolytes (urea, creatinine). Timepoint: At the beginning of the study, then daily until the end of the study. Method of measurement: AutoAnalyzer.	—

Measure

Time frame

Hemodynamic and blood supply findings (CO-MAP-HR). Timepoint: Measuring CO-MAP-HR at the beginning of the study (before the intervention) and then every hour until the end of the study. Method of measurement: Ecocardiography.;Vasopressor dependence days. Timepoint: The number of days that patients receive vasopressor. Method of measurement: Check list.;Urinary tract. Timepoint: At the beginning of the study and then every 6 hours until the end of the study. Method of measurement: Check list.;Duration of hospitalization in the intensive care unit. Timepoint: At the beginning of the study and then daily until the end of hospitalization in the relevant department. Method of measurement: Check list.;Serum lactate level. Timepoint: At the beginning of the study, then daily until the end of the study. Method of measurement: AutoAnalyzer.;Electrolytes (urea, creatinine). Timepoint: At the beginning of the study, then daily until the end of the study. Method of measurement: AutoAnalyzer.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKerman University of Medical Sciences

Kerman University of Medical Sciences

mehdia50@gmail.com+98 34 0223 5011

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026