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Effect of Acetaminophen on hemodynamic changes during intubation

Evaluation of the effect of Acetaminophen on hemodynamic changes during intubation in children undergoing hypospadias surgery

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20101220005426N10
Enrollment
126
Registered
2021-08-18
Start date
2021-09-23
Completion date
Unknown
Last updated
2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Intubation. Condition 2: Hypospadias. Failed or difficult intubation Hypospadias

Interventions

Intervention 1: Intervention group: Receiving Acetaminophen suppository at a dose of 15 mg per kg body weight of the child once rectally two hours before surgery (before intubation). Intervention 2: C

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
2 Years to 7 Years

Inclusion criteria

Inclusion criteria: Children undergoing hypospadias surgery Children aged 2 to 7 years

Exclusion criteria

Exclusion criteria: Known allergy to Acetaminophen Renal or hepatic impairment Bleeding disorders History of known heart or respiratory disease History of seizures Neurological or neuromuscular disorders History of chronic pain or use of pain medication Predict hard intubation

Design outcomes

Primary

MeasureTime frame
Systolic blood pressure. Timepoint: Checking of systolic blood pressure before induction of anesthesia, after induction of anesthesia and at 1, 3, 6 and 9 minutes after intubation. Method of measurement: Patient monitoring system.;Diastolic blood pressure. Timepoint: Checking of diastolic blood pressure before induction of anesthesia, after induction of anesthesia and at 1, 3, 6 and 9 minutes after intubation. Method of measurement: Patient monitoring system.;Heart rate. Timepoint: Checking of heart rate before induction of anesthesia, after induction of anesthesia and at 1, 3, 6 and 9 minutes after intubation. Method of measurement: Patient monitoring system.;Incidence of nausea and vomiting. Timepoint: Evaluation of nausea and vomiting during recovery and 6 hours after recovery. Method of measurement: Ask the child or parents of the child.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Ahmadinejad

Kerman University of Medical Sciences

mehdia50@gmail.com+98 34 3223 5011

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026