Comparison of Labetalol versus Hydralazin in control of Hypertension in preeclamptic patients and the out come of their pregnancy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201012185414N1

Enrollment

190

Registered

2011-08-24

Start date

2009-04-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preeclampsia. ???, ?????????? ? ???????? ???? ??? ?? ??????, ??? ??? ? ????

Interventions

Intervention 1: Hydralazin prescription in a 5 mg dose as first dose and blood pressure control after 20 minutes by first degree resident and repeat the same dose every 20 minutes up to 3 doses. Inter

Treatment - Drugs

Hydralazin prescription in a 5 mg dose as first dose and blood pressure control after 20 minutes by first degree resident and repeat the same dose every 20 minutes up to 3 doses

Labetalol prescription in a 20 mg dose as first dose and blood pressure control after 20 minutes by first degree resident and repeat the complimentary doses as 40 mg and 80 mg every 20 minutes up to 3

Eligibility

Sex/Gender

Female

Age

15 Years to 45 Years

Inclusion criteria

Inclusion criteria: Every pregnant woman by gestational age 20 to 42 weeks with a BP>160/105, singleton, estimated fetal weight < 4500 g Exclusion criteria: 1. History of basic chronic diseases ,including chronic HTN, hyperthyroidism, arrhythmia 2. Non cephalic presentation, macrosomia, thick meconium, previous history of caesarian section or uterine rupture which abdicate the option of NVD of patients. 3. History of long infertility, stillbirth, anomalous child, every reason for high risk pregnancy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hydralazin effect on control of Hypertension. Timepoint: 20minuts. Method of measurement: Mercurial Barometer.;Labetalol effect on control of Hypertension. Timepoint: 20 minutes. Method of measurement: Mercurial Barometer.	—

Secondary

Measure	Time frame
Maternal pulse rate control. Timepoint: 20minutes. Method of measurement: Maternal pulse rate control.;Average decreased amount of systolic blood pressure after Hydralazin administration. Timepoint: 20 minutes. Method of measurement: Mercurial Barometer.;Average decreased amount of diastolic blood pressure after Hydralazin administration. Timepoint: 20 minutes. Method of measurement: Mercurial Barometer.	—

Measure

Time frame

Maternal pulse rate control. Timepoint: 20minutes. Method of measurement: Maternal pulse rate control.;Average decreased amount of systolic blood pressure after Hydralazin administration. Timepoint: 20 minutes. Method of measurement: Mercurial Barometer.;Average decreased amount of diastolic blood pressure after Hydralazin administration. Timepoint: 20 minutes. Method of measurement: Mercurial Barometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Zohreh Tabasi

Kashan University of Medical Sience

tabasi_z @kaums.ac.ir; narges_oghbaee@yahoo.com+98 36144460180

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026