The effect of magnesium on muscular relaxation with cisatracorium

Study of the effect of magnesium sulfate 25 mg/kg & 50 mg/kg, on the speed of onset & intensity of muscle relaxation of cisatracurium during induction of anesthesia in the patients candidate for laparatomy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201012135378N1

Enrollment

Registered

2011-04-20

Start date

2009-12-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective intra abdominal surgery ( General & Gynecologic). Surgical procedure, unspecified

Interventions

Intervention 1: In the control group a single shut 100cc normal saline as placebo before induction of anesthesia. Intervention 2: In the first group of intervention ( group 2 study) 25 mg/kg magnesium

Placebo

Treatment - Drugs

In the control group a single shut 100cc normal saline as placebo before induction of anesthesia.

In the first group of intervention ( group 2 study) 25 mg/kg magnesium sulfate dissolved in 100cc normal saline infused intravenously over 10 min before anesthesia as single dose

In the second group (group 3 study) 50 mg/kg magnesium sulfate dissolved in 100cc normal saline infused in 10 min

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA I,II physical status class; 18 -60 years old; candidate for elective intra abdominal surgery under general anesthesia Exclusion criteria: History of neuromuscular, kidney, hepatic and cardiac diseases; hypo or hyper metabolic diseases; and those consuming drugs that affect neuromuscular junction; & history of cardiac arrhythmias.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Speed of muscle relaxation. Timepoint: After intervention. Method of measurement: Every second with nerve stimulator and single twitch test.	—

Secondary

Measure	Time frame
Quality & depth of muscle relaxation. Timepoint: 5 min after intervention. Method of measurement: Every 5 min with nerve stimulator and by post tetanic count test.;Heart rate & blood pressure variation. Timepoint: From arrival of the patient to OR until 30 min after intervention. Method of measurement: Every 5 min.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Aziz Seif MD.

Firoozghar Hospital, Tehran University of Medical Scienses

amir7044@yahoo.com+98 21889379025

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026