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Effect of Chlorhexidine 0.2% in a mucoadhesive polymeric gel from Carbomer and HPC on prevention of ventilator associated pneumonia

Comparison between mucoadhesive form from Carbomer and HydroxyPropylCellulose containing commercial chlorhexidine 0.2% and commercial chlorhexidine 0.2% solution for prevention of ventilator associated pneumonia in Intensive Care Unit (ICU) patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20101211005363N14
Enrollment
64
Registered
2019-11-15
Start date
2019-04-08
Completion date
Unknown
Last updated
2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ventilator associated pneumonia. Pneumonia in bacterial diseases classified elsewhere

Interventions

Intervention 1: Intervention group: The first group will receive 5 ml chlorhexidine 0.2% (product of Behsa pharmaceutical company) as mouthwash three times per day in a mucoadhesive form from Carbomer

Sponsors

Zanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age between 20 to 50 years Admission less than 24 hours in intensive care unit Intubated patient Satisfaction of patients' families

Exclusion criteria

Exclusion criteria: contraindications to any cause to enteral feeding pneumonia

Design outcomes

Primary

MeasureTime frame
Concentration of polymer in volume. Timepoint: At the beginning of experiment. Method of measurement: By weighing.;The amount of loading of cholorhexidine in gel. Timepoint: At the beginning of experiment. Method of measurement: By weighing.;The amount of release of cholorhexidine in gel. Timepoint: 1,2,3 and 4 hours after gel preparation. Method of measurement: Spectrophotometry.;Ventilator Associated Pneumonia. Timepoint: Third day, Sixth day, Ninth day, The twelfth day. Method of measurement: Clinical Pulmonary Infection Score.

Secondary

MeasureTime frame
Mortality rate during hospitalization in Intensive Care Unit. Timepoint: End of the study. Method of measurement: Records.;Connection to ventilator days. Timepoint: End of the study. Method of measurement: Records.;Length of Intensive Care Unit stay. Timepoint: End of the study. Method of measurement: Records.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarshad Khodami

Zanjan University of Medical Sciences

farshadkhodami@gmail.com+98 24 3345 9878

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026