Comparison study of the pre emptive of the two dose of dexmedetomidine (bolus and infusion) on post operative pain, nausea and vomiting for laparoscopic cholecystectomy

Comparison study of the preemptive of the two dose of dexmedetomidine (bolus and infusion) on post operative pain, nausea and vomiting for laparoscopic cholecystectomy

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20101211005362N31

Enrollment

Registered

2022-11-07

Start date

2022-07-23

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, nausea and vomiting.

Interventions

Intervention 1: Intervention group: Intravenous dexmedetomidine at a dose of 1 microgram per kilogram of body weight is given as a bolus dose 20 minutes before induction of anesthesia and then 0.5 mic

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: patient candidate to be operated laparoscopic cholecystectomy one and two ASA age between 18 - 65 year Patient consent to participate in the study

Exclusion criteria

Exclusion criteria: Drug addiction History of dexmedetomidine allergy People with a BMI above 30 Use of sleeping pills and analgesics chronically

Design outcomes

Primary

Measure	Time frame
Comparison of the effect of different doses of dexmedetomidine on amount of pain. Timepoint: The first hour of recovery every 15 minutes, then 6 hours later, every two hours, and then 12, 24 and 48 hours later is evaluated. Method of measurement: Pain intensity based on VAS scoring system and severity of nausea and vomiting using PONV system.;Comparing the effect of different doses of dexmedetomidine on nausea severity. Timepoint: The first hour of recovery every 15 minutes, then 6 hours later every two hours, and then 12, 24 and 48 hours later is evaluated. Method of measurement: The severity of nausea is measured using the PONV system.;Comparing the effect of different doses of dexmedetomidine on vomiting severity. Timepoint: The first hour of recovery every 15 minutes, then 6 hours later, every two hours, and then 12, 24 and 48 hours later is evaluated. Method of measurement: The severity of vomiting is measured using the PONV system.	—

Measure

Time frame

Comparison of the effect of different doses of dexmedetomidine on amount of pain. Timepoint: The first hour of recovery every 15 minutes, then 6 hours later, every two hours, and then 12, 24 and 48 hours later is evaluated. Method of measurement: Pain intensity based on VAS scoring system and severity of nausea and vomiting using PONV system.;Comparing the effect of different doses of dexmedetomidine on nausea severity. Timepoint: The first hour of recovery every 15 minutes, then 6 hours later every two hours, and then 12, 24 and 48 hours later is evaluated. Method of measurement: The severity of nausea is measured using the PONV system.;Comparing the effect of different doses of dexmedetomidine on vomiting severity. Timepoint: The first hour of recovery every 15 minutes, then 6 hours later, every two hours, and then 12, 24 and 48 hours later is evaluated. Method of measurement: The severity of vomiting is measured using the PONV system.

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Secondary

Measure	Time frame
Blood pressure. Timepoint: The first hour of recovery is evaluated every 15 minutes, then 6 hours later, every two hours, and then 12, 24 and 48 hours later. Method of measurement: Blood pressure is measured using a sphygmomanometer.;Heart beat. Timepoint: The first hour of recovery is evaluated every 15 minutes, then every two hours after 6 hours, and then 12, 24, and 48 hours later. Method of measurement: Heart rate is measured using a pulse oximeter.;Blood oxygen level. Timepoint: The first hour of recovery is evaluated every 15 minutes, then every two hours after 6 hours, and then 12, 24, and 48 hours later. Method of measurement: Blood oxygen is measured using a pulse oximeter.;Amount of drugs. Timepoint: The first hour of recovery is evaluated every 15 minutes, then every two hours after 6 hours, and then 12, 24, and 48 hours later. Method of measurement: Using the volume in cc used.	—

Measure

Time frame

Blood pressure. Timepoint: The first hour of recovery is evaluated every 15 minutes, then 6 hours later, every two hours, and then 12, 24 and 48 hours later. Method of measurement: Blood pressure is measured using a sphygmomanometer.;Heart beat. Timepoint: The first hour of recovery is evaluated every 15 minutes, then every two hours after 6 hours, and then 12, 24, and 48 hours later. Method of measurement: Heart rate is measured using a pulse oximeter.;Blood oxygen level. Timepoint: The first hour of recovery is evaluated every 15 minutes, then every two hours after 6 hours, and then 12, 24, and 48 hours later. Method of measurement: Blood oxygen is measured using a pulse oximeter.;Amount of drugs. Timepoint: The first hour of recovery is evaluated every 15 minutes, then every two hours after 6 hours, and then 12, 24, and 48 hours later. Method of measurement: Using the volume in cc used.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Safavi

Esfahan University of Medical Sciences

safavi@med.mui.ac.ir+98 31 1625 5555

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026