effect of Ketamine gargle on post-operative sore throat

Prophylactic effects of Ketamine gargle on post-operative sore throat: A double blinded randomized controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20101211005362N22

Enrollment

Registered

2018-09-17

Start date

2018-09-20

Completion date

Unknown

Last updated

2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intubation side effect.

Interventions

Intervention 1: Intervention group: Group K received 50 mg Ketamine solved in 29 ml saline. Intervention 2: Intervention group: , group G received 100 mg Ketamine solved in 28 ml saline. Intervention

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: patients in class I and II American Society of Anesthesiologists (ASA) classification system, age range of 18-65 years old candidates of elective septoplasty surgery with general anesthesia no pre-operative sore throat no asthma no sensitivity to using drugs.

Exclusion criteria

Exclusion criteria: endotracheal tube intubation more than one time change of anesthetic technique.

Design outcomes

Primary

Measure	Time frame
Post operative sore throat. Timepoint: time 1 was immediately after entrance to recovery room , time 2 was 2 hours post operation , time 3 was 4 hours post operation , time 4 was 8 hours post operation and time 5 was 24 hours after operation. Method of measurement: . Score 0 defined as no sore throat. Score 1 defined as mild sore throat which means sore throat complain only after patients were asked. Score 2 defined as moderate sore throat which means patients complained about sore throat at recovery room before they were asked. Score 3 defined as severe sore throat which means vocal changes or sore throat with hoarseness.	—

Measure

Time frame

Post operative sore throat. Timepoint: time 1 was immediately after entrance to recovery room , time 2 was 2 hours post operation , time 3 was 4 hours post operation , time 4 was 8 hours post operation and time 5 was 24 hours after operation. Method of measurement: . Score 0 defined as no sore throat. Score 1 defined as mild sore throat which means sore throat complain only after patients were asked. Score 2 defined as moderate sore throat which means patients complained about sore throat at recovery room before they were asked. Score 3 defined as severe sore throat which means vocal changes or sore throat with hoarseness.

—

Secondary

Measure	Time frame
Complications like headache, nausea, vomiting, dizziness, cough and laryngospasm. Timepoint: time 1 was immediately after entrance to recovery room , time 2 was 2 hours post operation , time 3 was 4 hours post operation , time 4 was 8 hours post operation and time 5 was 24 hours after operation. Method of measurement: asking patients and observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Safavi

Esfahan University of Medical Sciences

safavi@med.mui.ac.ir+98 31 3222 2135

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026